Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …

The term metastasis is widely used to describe the endpoint of the process by which tumour
cells spread from the primary location to an anatomically distant site. Achieving successful …

Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …

The new generation androgen receptor (AR) pathway inhibitor enzalutamide can prolong
the survival of patients with metastatic prostate cancer. However, resistance to enzalutamide …

Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are
the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS …

Tamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for
estrogen receptor (ER)‐positive breast cancer patients. Cullin 4B (CUL4B), which acts as a …

Although enzalutamide improves the overall survival of patients with metastatic prostate
cancers, enzalutamide resistance (ENZR) will be inevitably developed. Emerging evidence …

Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease. Macrophage
infiltration in the kidney is critical for the progression of DKD. However, the underlying …

CUL4B, which acts as a scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B)
complexes, participates in a variety of biological processes. Previous studies have shown …

Background Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, is overexpressed in many types of solid tumors and contributes to epigenetic …