MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer
M Hu, S Zhu, S Xiong, X Xue… - Oncology reports, 2019 - spandidos-publications.com
Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …
Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer
The term metastasis is widely used to describe the endpoint of the process by which tumour
cells spread from the primary location to an anatomically distant site. Achieving successful …
cells spread from the primary location to an anatomically distant site. Achieving successful …
RUNX2 recruits the NuRD (MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis
X Yin, X Teng, T Ma, T Yang, J Zhang, M Huo… - Cell Death & …, 2022 - nature.com
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
KIF15-mediated stabilization of AR and AR-V7 contributes to enzalutamide resistance in prostate cancer
L Gao, W Zhang, J Zhang, J Liu, F Sun, H Liu, J Hu… - Cancer Research, 2021 - AACR
The new generation androgen receptor (AR) pathway inhibitor enzalutamide can prolong
the survival of patients with metastatic prostate cancer. However, resistance to enzalutamide …
the survival of patients with metastatic prostate cancer. However, resistance to enzalutamide …
CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells
X Liu, F Tian, J Cui, L Gong, L Xiang, B Fan, S Liu… - Oncogene, 2023 - nature.com
Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are
the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS …
the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS …
CUL4B renders breast cancer cells tamoxifen‐resistant via miR‐32‐5p/ER‐α36 axis
Y Wang, X Pan, Y Li, R Wang, Y Yang… - The Journal of …, 2021 - Wiley Online Library
Tamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for
estrogen receptor (ER)‐positive breast cancer patients. Cullin 4B (CUL4B), which acts as a …
estrogen receptor (ER)‐positive breast cancer patients. Cullin 4B (CUL4B), which acts as a …
RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway
F Sun, X Wang, J Hu, J Liu, X Wang, W Jia, Z Yu, L Gao… - Oncogene, 2022 - nature.com
Although enzalutamide improves the overall survival of patients with metastatic prostate
cancers, enzalutamide resistance (ENZR) will be inevitably developed. Emerging evidence …
cancers, enzalutamide resistance (ENZR) will be inevitably developed. Emerging evidence …
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis
S Jin, Y Song, L Zhou, W Jiang, L Qin, Y Wang, R Yu… - Cell Reports, 2023 - cell.com
Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease. Macrophage
infiltration in the kidney is critical for the progression of DKD. However, the underlying …
infiltration in the kidney is critical for the progression of DKD. However, the underlying …
The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer
X Liu, J Cui, L Gong, F Tian, Y Shen, L Chen, Y Wang… - Oncogene, 2020 - nature.com
CUL4B, which acts as a scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B)
complexes, participates in a variety of biological processes. Previous studies have shown …
complexes, participates in a variety of biological processes. Previous studies have shown …
CUL4B/miR‐33b/C‐MYC axis promotes prostate cancer progression
M Zhao, M Qi, X Li, J Hu, J Zhang, M Jiao, X Bai… - The …, 2019 - Wiley Online Library
Background Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, is overexpressed in many types of solid tumors and contributes to epigenetic …
complexes, is overexpressed in many types of solid tumors and contributes to epigenetic …