The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Modularity plays a fundamental role in the prediction of the behavior of a system from the
behavior of its components, guaranteeing that the properties of individual components do …

Considerable progress has been made in identifying the molecular composition of complex
signaling networks controlling cell proliferation, differentiation, and survival. However, to …

Abstract Systems biology applies quantitative, mechanistic modelling to study genetic
networks, signal transduction pathways and metabolic networks. Mathematical models of …

Mathematical and computational modeling is rapidly becoming an essential research
technique complementing traditional experimental biological methods. However, lack of …

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook,
Fourth Edition, sets the standard against which all other references of this nature are …

As biology begins to move into the ''postgenomic''era, a key emerging question is how to
approach the understanding of how complex biomolecular networks function as dynamical …

In recent years, mathematical modelling of developmental processes has earned new
respect. Not only have mathematical models been used to validate hypotheses made from …