The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Although p53-mediated cell-cycle arrest, senescence, and apoptosis remain critical barriers
to cancer development, the emerging role of p53 in cell metabolism, oxidative responses …

Abstract ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated
in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome—a …

The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential
class of metabolites found throughout all kingdoms of life. In this comprehensive review, we …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Heavy metal (HM) toxicity is one of the major abiotic stresses leading to hazardous effects in
plants. A common consequence of HM toxicity is the excessive accumulation of reactive …