Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Human menopause is widely associated with impaired skeletal muscle quality and
significant metabolic dysfunction. These observations pose significant challenges to the …

Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

Red meat has been an important part of the diet throughout human evolution. Overall, when
included as part of a healthy and varied diet, red meat can provide a rich source of …

Glucose is central to energy consumption. Carbohydrates, lipids, and proteins all ultimately
break down into glucose, which then serves as the primary metabolic fuel of mammals and …

Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Insulin is the master regulator of glucose, lipid, and protein metabolism. Following ingestion
of an oral glucose load or mixed meal, the plasma glucose concentration rises, insulin …

Deep eutectic solvent as a new green and safe solvent system has attracted more and more
attention in recent years. In this study, three deep eutectic solvents (DES) were combined …

Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle
wasting in mammals. However, the molecular events that mediate glucocorticoid-induced …