Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Ethnopharmacological relevance Chemotherapy is a common cancer treatment strategy.
However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae …

Microplastics cause varying degrees of damage to aquatic organisms. Exposure to
microplastics contaminated water, the gills are among the first tissues, after the skin, to be …

Background Doxorubicin (DOX) is a powerful anti-tumor anthracycline drug. However, its
clinical use is limited due to the side effect of cardiotoxicity. Tanshinone I (Tan I) is one of the …

Rationale: Anthracycline-induced cardiotoxicity (AIC) is a major side effect that limits the use
of anthracyclines as effective chemotherapeutics. No mechanism-based therapy is available …

Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of
antioxidative stress responses, which are associated with ferroptosis inhibition. Ferroptosis …

Doxorubicin (DOX) is an effective antitumor drug; however, but its clinical application is
seriously limited by the cardiotoxicity induced by its use. Recent studies have found that …

The incidence of cardiovascular disorders is one of the most concerns among people who
underwent cancer therapy. The heart side effects of cancer therapy may occur during …

Doxorubicin (DOX) has received attention due to dose-dependent cardiotoxicity through
abnormal redox cycling. Native fibroblast growth factor 1 (FGF1) is known for its anti …

Simple Summary The use of date palm pollen ethanolic extract (DPPE) is a conventional
approach in improving the side-effects induced by Doxorubicin (DOX). DPPE mitigated DOX …