Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed
countries. Its frequency is increasing in the general population mostly due to the widespread …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Drugs are capable of inducing hepatic lipid accumulation. When fat accumulates, lipids are
primarily stored as triglycerides which results in steatosis and provides substrates for lipid …

Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …

Amiodarone is prescribed for the treatment and prevention of irregular heartbeats. Although
effective in clinical practice, the long-term use of amiodarone has many unwanted side …

ИВ Маев, ДН Андреев ГБОУ ВПО МГМСУ им. АИ Евдокимова Минздрава РФ ния,
длительное парентеральное питание, синдром избыточного бактериального …

Hepatic steatosis is characterized by the accumulation of lipid droplets in the liver. Although
relatively benign, simple steatosis can eventually lead to the development of steatohepatitis …

Nonalcoholic steatosis/steatohepatitis is the most common cause for abnormal liver
chemistries. Apart from metabolic syndrome, drugs may also lead to development of …

Introduction. Amiodarone has been used for more than 5 decades for the treatment of
various tachyarrhythmias and previously for the treatment of refractory angina. There are …