Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

The tumor microenvironment is a complex ecosystem comprised of many different cell types,
abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with …

Exosomes (EXOs) have been proven as biomarkers for disease diagnosis and agents for
therapeutics. Great challenge remains in the separation of EXOs with high-purity and low …

An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …

Cellulose is a naturally existing element in the plant's cell wall and in several bacteria. The
unique characteristics of bacterial cellulose (BC), such as non-toxicity, biodegradability …

Reactive oxygen species (ROS) play a crucial role in physiological and pathological
processes, emerging as a therapeutic target in cancer. Owing to the high concentration of …

Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …

Cobalt (Co) ions, which can mimic hypoxia to promote angiogenesis, exhibit great potential
for bone repair. However, a key point for the use of Co ions is that their release profile …

During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …

Development of the early embryo takes place under low oxygen tension. Under such
conditions, the embryo implants and the trophectoderm, the outer layer of blastocyst …