Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second
messenger that binds and activates the adaptor protein STING, which leads to interferon …

Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …

Abstract γδ T cells have several innate cell-like features that allow their early activation
following recognition of conserved stress-induced ligands. Here we review recent …

The main function of the mammalian immune system is to monitor tissue homeostasis, to
protect against invading or infectious pathogens and to eliminate damaged cells. Therefore …

Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …

Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell
surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell …

MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs),
which are expressed by natural killer cells and T cells. The interactions between these …