A further meeting, sponsored by WHO, was held on 4-8 December 1995 in Geneva. The
purpose was to review in great detail the latest scientific evidence for, and practical …

Malaria is associated with a reduction in the systemic clearance and apparent volume of
distribution of the cinchona alkaloids; this reduction is proportional to the disease severity …

Participants in both consultations Dr CJ Canfield, Pharmaceutical Systems Incorporated,
Gaithersburg, Maryland, United States of America.

The aim of this work was to formulate and characterize thermosensitive gels based on
poloxamer 407, a thermosensitive polymer, and hydroxypropylmethylcellulose (HPMC), a …

Taking readers from the research laboratory to the bedside, this Second Edition compiles
essential information on the pharmacodynamics of all major classes of the antimicrobial …

Background Many patients with malaria of increasing severity cannot take medicines orally,
and delay in injectable treatment can be fatal. We aimed to assess the reliability of …

Background Electrocardiographic QT interval prolongation is the most widely used risk
marker for ventricular arrhythmia potential and thus an important component of drug …

Background Malaria remains a serious health problem because resistance develops to all
currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are …

1. Plasma concentrations of alpha 1‐acid glycoprotein (AAG) and plasma protein binding of
quinine were measured in 97 Thai adults with acute falciparum malaria. There was a linear …

Cerebral malaria is a rapidly progressive encephalopathy with up to 50% mortality. A
cardinal feature is the massing of red cells containing mature Plasmodium falciparum within …