Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

Two decades ago, the recognition of protein misfolding and aggregate accumulation as
defining features of neurodegenerative disease set the stage for a thorough examination of …

Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth and
progression. The first biochemical descriptions of the altered metabolic nature of solid …

Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors,
including gastric cancer (GC). However, there are still many circRNAs related to GC whose …

Abstract Background Prostate cancer (PCa) is one of the most prevalent cancers that occur
in men worldwide. Autophagy-related genes (ARGs) may play an essential role in multiple …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and
lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage …