Significance of Chalcone Scaffolds in Medicinal Chemistry

R Mazumder, A Ghosh, S Deb, R Ghosh - Topics in Current Chemistry, 2024 - Springer
Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

[HTML][HTML] A Novel Tri-Hydroxy-Methylated Chalcone Isolated from Chromolaena tacotana with Anti-Cancer Potential Targeting Pro-Survival Proteins

G Mendez-Callejas, M Piñeros-Avila… - International Journal of …, 2023 - mdpi.com
Chromolaena tacotana (Klatt) RM King and H. Rob (Ch. tacotana) contains bioactive
flavonoids that may have antioxidant and/or anti-cancer properties. This study investigated …

[HTML][HTML] Multienzymatic biotransformation of flavokawain B by entomopathogenic filamentous fungi: structural modifications and pharmacological predictions

P Chlipała, T Tronina, M Dymarska, M Urbaniak… - Microbial Cell …, 2024 - Springer
Background Flavokawain B is one of the naturally occurring chalcones in the kava plant
(Piper methysticum). It exhibits anticancer, anti-inflammatory and antimalarial properties …

[HTML][HTML] Natural 2′,4-Dihydroxy-4′,6′-dimethoxy Chalcone Isolated from Chromolaena tacotana Inhibits Breast Cancer Cell Growth through Autophagy and …

G Mendez-Callejas, M Piñeros-Avila, CA Celis… - Plants, 2024 - mdpi.com
Breast cancer (BC) is one of the most common cancers among women. Effective treatment
requires precise tailoring to the genetic makeup of the cancer for improved efficacy …

Chalcones: Effective Agents for Fighting Cancer Across Multiple Cell Lines

S Kaur, J Kaur, A Anand, K Kaur… - ChemistrySelect, 2024 - Wiley Online Library
This review article explores the mushrooming research on chalcone hybrid molecules as
promising anticancer agents. Chalcones, featuring a unique chemical structure, exhibit …

Isocoumarins incorporating chalcone moieties act as isoform selective tumor-associated carbonic anhydrase inhibitors

M Onyilmaz, M Koca, A Ammara… - Future Medicinal …, 2024 - Taylor & Francis
Aim: A series of isocoumarin–chalcone hybrids were prepared and assays for the inhibition
of four isoforms of human carbonic anhydrase (hCA; EC 4.2. 1.1), hCA I, II, IX and XII …

[HTML][HTML] Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer

JMM Mohamed, F Ahmad, M El-Sherbiny… - Cancer …, 2024 - Springer
Background Colorectal cancer (CRC) is a type of cancer that affects the colon or rectum and
occurs in individuals over the age of 50, although it can affect people of all ages. Quercetin …

[HTML][HTML] Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity

M Mari, M Boniburini, M Tosato, L Rigamonti… - International Journal of …, 2023 - mdpi.com
With the clear need for better cancer treatment, naturally occurring molecules represent a
powerful inspiration. Recently, curcumin has attracted attention for its pleiotropic anticancer …

[HTML][HTML] Targeting Ovarian Cancer with Chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells

E Merve Aydin, İS Canıtez, E Colombo, S Princiotto… - Molecules, 2023 - mdpi.com
Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the
globe and stands as the third most frequent gynecological cancer, following cervical and …

[HTML][HTML] Anti-inflammatory, antithrombotic and anti-oxidant bioactives of beer and brewery by-products, as ingredients of bio-functional foods, nutraceuticals, cosmetics …

A Tsoupras, EA Panagopoulou… - AIMS Agriculture and …, 2024 - aimspress.com
Fermented alcoholic beverages and their by-products, including beer and breweries' bio-
wastes like spent yeasts, grain, and hops, contain a plethora of natural bioactive compounds …