Cancer stem cell and hepatic stellate cells in hepatocellular carcinoma

AG Quiroz Reyes… - … in Cancer Research …, 2023 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is the most common liver cancer. It is highly lethal and has
high recurrence. Death among HCC patients occur mainly due to tumor progression …

Innate immunity and early liver inflammation

J Yang Zhou - Frontiers in Immunology, 2023 - frontiersin.org
The innate system constitutes a first-line defence mechanism against pathogens. 80% of the
blood supply entering the human liver arrives from the splanchnic circulation through the …

(E)-2-((3-nitrophenyl) diazenyl)-3-oxo-3-phenylpropanal: experimental, DFT studies, and molecular docking investigations

EC Agwamba, H Louis, I Benjamin, CG Apebende… - Chemistry Africa, 2022 - Springer
In 2019 alone, the WHO declared about 325 million people worldwide to be infected with
hepatitis, resulting to mortality of about 1.4 million annually. In this study the potential of (E)-2 …

Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury

M Abdelnaser, R Alaaeldin, ME Attya… - … schmiedeberg's Archives of …, 2024 - Springer
Purpose Globally, sepsis, which is a major health issue resulting from severe infection-
induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for …

Quercetin potentiates the hepatoprotective effect of sildenafil and/or pentoxifylline against intrahepatic cholestasis: Role of Nrf2/ARE, TLR4/NF-κB, and NLRP3/IL-1β …

MA Fawzy, G Nasr, FEM Ali, M Fathy - Life Sciences, 2023 - Elsevier
Aim Intrahepatic cholestasis is a common pathological condition of several types of liver
disorders. In this study, we aimed to investigate the regulatory effects of quercetin (QU) on …

Azilsartan modulates HMGB1/NF-κB/p38/ERK1/2/JNK and apoptosis pathways during renal ischemia reperfusion injury

R Alaaeldin, SM Bakkar, RH Mohyeldin, FEM Ali… - Cells, 2023 - mdpi.com
Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of
blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for …

A New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition

R Alaaeldin, HA Hassan, IM Abdel-Rahman… - Current Issues in …, 2022 - mdpi.com
Inflammation is a critical defensive mechanism mainly arising due to the production of
prostaglandins via cyclooxygenase enzymes. This study aimed to examine the anti …

Uncovering the immune microenvironment and molecular subtypes of hepatitis B-related liver cirrhosis and developing stable a diagnostic differential model by …

S Zhang, C Jiang, L Jiang, H Chen, J Huang… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Hepatitis B-related liver cirrhosis (HBV-LC) is a common clinical disease that
evolves from chronic hepatitis B (CHB). The development of cirrhosis can be suppressed by …

Curative Effect of AD‐MSCs against Cisplatin‐Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling …

AA Bekhit, ON Beshay, MA Fawzy… - Stem Cells …, 2023 - Wiley Online Library
Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via
inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore …

[HTML][HTML] Recent advances in recurrent hepatocellular carcinoma therapy

YX Gao, QQ Ning, PX Yang, YY Guan… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer,
accounting for 75%-85% of cases. Although treatments are given to cure early-stage HCC …