Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this
study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different …

Objective: To evaluate the physiological effects of electrospun tropoelastin scaffolds as
therapeutic adipose-derived stem cell (ADSC) delivery vehicles for the treatment of full …

Porcine skin is commonly used as a model for human skin injury and as a source material
for biologic scaffold materials. Although remarkable similarities between porcine and human …

Wound contracture, which commonly happens after wound healing, may lead to physical
distortion, including skin constriction. Therefore, the combination of collagen and elastin as …

Cartilage regeneration remains a challenge in the field of regenerative medicine. Advances
in cartilage regeneration would greatly benefit patients requiring reconstructive surgeries as …

As a potential alternative to currently available skin substitutes and wound dressings, we
explored the use of bioactive scaffolds made of plant‐derived proteins. We hypothesized …

There is a global demand for the development and production of acellular and cellular skin
substitutes for human skin replacement therapy and for industrial testing of pharmaceuticals …

Elastin is the dominant mammalian elastic protein found in soft tissue. Elastin-based
biomaterials have the potential to repair elastic tissues by improving local elasticity and …

Background: Although wound contraction is an essential part of healing, excessive
contraction can compromise healing through induction of scarring and fibrosis. This in turn …

Severe burn injury results in substantial skin loss and cannot be treated by autografts. The
Integra Dermal Regeneration Template (IDRT) is the leading synthetic skin substitute …