BRCA1 gene in breast cancer
EM Rosen, S Fan, RG Pestell… - Journal of cellular …, 2003 - Wiley Online Library
The BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast
cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of …
cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of …
American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and …
RT Chlebowski, N Col, EP Winer, DE Collyar… - Journal of Clinical …, 2002 - ascopubs.org
OBJECTIVE: To update an evidence-based technology assessment of chemoprevention
strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen …
strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen …
Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer
Background & Aims We investigated the prevalence of germline mutations in APC, ATM,
BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 …
BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 …
Risk factors and risk reduction of breast and ovarian cancer
CTM Brekelmans - Current opinion in Obstetrics and Gynecology, 2003 - journals.lww.com
During the period of this review, the importance of several known risk factors was confirmed,
whereas the effects of other factors became more clear. Chemoprevention and prophylactic …
whereas the effects of other factors became more clear. Chemoprevention and prophylactic …
ER-positive and BRCA2-mutated breast cancer: a literature review
PC Li, YF Zhu, WM Cao, B Li - European Journal of Medical Research, 2024 - Springer
BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of
onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate …
onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate …
Clinical Considerations of BRCA1‐ and BRCA2‐Mutation Carriers: A Review
O Bougie, JI Weberpals - International journal of surgical …, 2011 - Wiley Online Library
Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2
genes have a significant risk of developing breast and ovarian cancer over the course of …
genes have a significant risk of developing breast and ovarian cancer over the course of …
Identifying and testing for hereditary susceptibility to common cancers
R Sifri, S Gangadharappa… - CA: A Cancer journal for …, 2004 - Wiley Online Library
Hereditary cancer syndromes account for an estimated 5% of breast, ovarian, and colon
cancers. The rapid discovery of cancer‐related genes in the last 15 years has propelled the …
cancers. The rapid discovery of cancer‐related genes in the last 15 years has propelled the …
Tamoxifen for breast cancer chemoprevention: low uptake by high-risk women after evaluation of a breast lump
R Taylor, K Taguchi - The Annals of Family Medicine, 2005 - Annals Family Med
PURPOSE The Breast Cancer Prevention Trial (BCPT) published results in 1998 showing
that the use of tamoxifen in high-risk women reduced the incidence of invasive breast cancer …
that the use of tamoxifen in high-risk women reduced the incidence of invasive breast cancer …
The role of prophylactic surgery in cancer prevention
YN You, VT Lakhani, SA Wells - World journal of surgery, 2007 - Springer
Background Since the human genome has been sequenced many mysteries of cell biology
have been unravelled, thereby clarifying the pathogenesis of several diseases, particularly …
have been unravelled, thereby clarifying the pathogenesis of several diseases, particularly …
Assessing the effectiveness of the National Comprehensive Cancer Network genetic testing guidelines in identifying African American breast cancer patients with …
FO Ademuyiwa, P Salyer, Y Ma, S Fisher… - Breast Cancer Research …, 2019 - Springer
Purpose Approximately, 10% of breast cancers are hereditary. Identifying women at high risk
for hereditary breast and ovarian cancer allows for early detection, prevention, and …
for hereditary breast and ovarian cancer allows for early detection, prevention, and …