[HTML][HTML] Biomarkers for the early detection and progression of Alzheimer's disease

SE Counts, MD Ikonomovic, N Mercado, IE Vega… - …, 2017 - Elsevier
The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer's disease

DA Loewenstein, RE Curiel, R Duara… - …, 2018 - journals.sagepub.com
In spite of advances in neuroimaging and other brain biomarkers to assess preclinical
Alzheimer's disease (AD), cognitive assessment has relied on traditional memory paradigms …

Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway

VR Varma, S Varma, Y An, TJ Hohman… - Molecular …, 2017 - nature.com
Preclinical changes that precede the onset of symptoms and eventual diagnosis of
Alzheimer's disease (AD) are a target for potential preventive interventions. A large body of …

[HTML][HTML] Development and validation of a salivary tau biomarker in Alzheimer's disease

H Pekeles, HY Qureshi, HK Paudel… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Total tau (t-tau) and phosphorylated tau (p-tau) are abnormally elevated in the
brain and cerebrospinal fluid of individuals with Alzheimer's disease (AD). Tau is also …

Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: a literature review

KEJ Wesenhagen, CE Teunissen… - Critical reviews in …, 2020 - Taylor & Francis
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
aggregation of amyloid and tau proteins in the brain. Results from genetic studies suggest …

[HTML][HTML] DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

N Schwab, K Grenier, LN Hazrati - Acta Neuropathologica …, 2019 - Springer
Mild traumatic brain injury (mTBI) leads to diverse symptoms including mood disorders,
cognitive decline, and behavioral changes. In some individuals, these symptoms become …

Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults

BE Snitz, DL Tudorascu, Z Yu… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery
(NIHTB‐CB) was developed to be a common assessment metric across a broad array of …

Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: a monozygotic twin study

J Tomassen, A Den Braber… - … Research & Clinical …, 2022 - Wiley Online Library
Introduction The contribution of genetic and environmental factors to the relation between
cerebrospinal fluid (CSF) biomarkers and cognitive decline in preclinical Alzheimer's …

Cognitive variability predicts incident Alzheimer's disease and mild cognitive impairment comparable to a cerebrospinal fluid biomarker

CE Gleason, D Norton, ED Anderson… - Journal of …, 2018 - content.iospress.com
Background: Alzheimer's disease (AD) biomarkers are emerging as critically important for
disease detection and monitoring. Most biomarkers are obtained through invasive, resource …

[HTML][HTML] Cholinesterase inhibitory activity, antioxidative potential and microbial stability of innovative liver pâté fortified with rosemary extract (Rosmarinus officinalis)

A Bilska, J Kobus-Cisowska, D Kmiecik… - Electronic Journal of …, 2019 - Elsevier
Abstract Background Rosemary (Rosmarinus officinalis) contains active substances that
have desirable properties for industrial and herbal medicine applications, eg, essential oils …