New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era

NL Kuehnbaum, P Britz-McKibbin - Chemical reviews, 2013 - ACS Publications
Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Multidimensional gas chromatography: fundamental advances and new applications

JV Seeley, SK Seeley - Analytical Chemistry, 2013 - ACS Publications
Multidimensional gas chromatography (MDGC) is a tech-nique for isolating and identifying
volatile and semi-volatile organic compounds present in complex mixtures. MDGC …

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

J Wirbel, PT Pyl, E Kartal, K Zych, A Kashani… - Nature medicine, 2019 - nature.com
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross …

[HTML][HTML] Importance of fatty acids in physiopathology of human body

K Nagy, ID Tiuca - Fatty acids, 2017 - intechopen.com
Fatty acids are important components of the human body, having biological, structural and
functional roles. Besides their role as source of energy, they act as main constituents of …

Metabolomics in diagnosis and biomarker discovery of colorectal cancer

A Zhang, H Sun, G Yan, P Wang, Y Han, X Wang - Cancer letters, 2014 - Elsevier
Colorectal cancer (CRC), a major public health concern, is the second leading cause of
cancer death in developed countries. There is a need for better preventive strategies to …

Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery

Y Ni, G Xie, W Jia - Journal of proteome research, 2014 - ACS Publications
Colorectal cancer (CRC) is one of the most common cancers in the world, having both high
prevalence and mortality. It is usually diagnosed at advanced stages due to the limitations of …

Review of mass spectrometry–based metabolomics in cancer research

DB Liesenfeld, N Habermann, RW Owen… - … , biomarkers & prevention, 2013 - AACR
Metabolomics, the systematic investigation of all metabolites present within a biologic
system, is used in biomarker development for many human diseases, including cancer. In …

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

I Kahouli, C Tomaro-Duchesneau… - Journal of medical …, 2013 - microbiologyresearch.org
Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as
chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited …

A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics

F Farshidfar, AM Weljie, KA Kopciuk, R Hilsden… - British journal of …, 2016 - nature.com
Background: Timely diagnosis and classification of colorectal cancer (CRC) are hindered by
unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series …

Analytical protocols based on LC–MS, GC–MS and CE–MS for nontargeted metabolomics of biological tissues

S Naz, DC Moreira dos Santos, A García, C Barbas - Bioanalysis, 2014 - Taylor & Francis
Invasive, site-specific metabolite information could be better obtained from tissues. Hence,
highly sensitive mass spectrometry-based metabolomics coupled with separation …