Alginate oligosaccharides: The structure-function relationships and the directional preparation for application

S Lu, K Na, J Wei, L Zhang, X Guo - Carbohydrate Polymers, 2022 - Elsevier
Alginate oligosaccharides (AOS) are degradation products of alginate extracted from brown
algae. With low molecular weight, high water solubility, and good biological activity, AOS …

Recent advances in the production, properties and applications of alginate oligosaccharides-a mini review

L Li, J Jiang, Z Yao, B Zhu - World Journal of Microbiology and …, 2023 - Springer
Alginate oligosaccharides (AOS) made from the degradation of alginate, to some extent,
makes up for the poor solubility and bioavailability of alginate as a macromolecular …

Preparation and potential applications of alginate oligosaccharides

D Bi, X Yang, J Lu, X Xu - Critical Reviews in Food Science and …, 2023 - Taylor & Francis
Alginate, a linear polymer consisting of β-D-mannuronic acid (M) and α-L-guluronic acid (G)
with 1, 4-glycosidic linkages and comprising 40% of the dry weight of algae, possesses …

Polyguluronic acid alleviates doxorubicin-induced cardiotoxicity by suppressing Peli1-NLRP3 inflammasome-mediated pyroptosis

E Zhang, C Shang, M Ma, X Zhang, Y Liu, S Song… - Carbohydrate …, 2023 - Elsevier
Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities.
We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average …

Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

S Xie, SC Xu, W Deng, Q Tang - Signal Transduction and Targeted …, 2023 - nature.com
Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Patchouli alcohol inhibits D‐gal induced oxidative stress and ameliorates the quality of aging cartilage via activating the Nrf2/HO‐1 pathway in mice

M Chen, H Wen, S Zhou, X Yan… - Oxidative Medicine and …, 2022 - Wiley Online Library
Chondrocytes play an essential role in maintaining the structure and function of articular
cartilage. Oxidative stress occurred in chondrocytes accelerates cell senescence and death …

Alginate oligosaccharide alleviates aging-related intestinal mucosal barrier dysfunction by blocking FGF1-mediated TLR4/NF-κB p65 pathway

Y Wang, K Ren, J Tan, Y Mao - Phytomedicine, 2023 - Elsevier
Background Alginate oligosaccharide (AOS) has been reported to exert a crucial role in
maintaining the intestinal mucosal barrier (IMB) function. The current study aimed at …

Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti-Inflammatory, and …

HI Ghamry, M Shukry, MA Kassab… - International Journal …, 2023 - Taylor & Francis
Background Loss of normal function is an inevitable effect of aging. Several factors
contribute to the aging process, including cellular senescence and oxidative stress. Methods …

Nobiletin prevents D-galactose-induced C2C12 cell aging by improving mitochondrial function

HH Wang, YN Sun, TQ Qu, XQ Sang, LM Zhou… - International journal of …, 2022 - mdpi.com
Age-associated loss of skeletal muscle mass and function is one of the main causes of the
loss of independence and physical incapacitation in the geriatric population. This study used …

Oligosaccharides as potential therapeutics against atherosclerosis

SA Dabravolski, VN Sukhorukov, AA Melnichenko… - Molecules, 2023 - mdpi.com
Atherosclerosis is the major cause of cardiovascular-disease-related death worldwide,
resulting from the subendothelial accumulation of lipoprotein-derived cholesterol, ultimately …