An overview of new antitubercular drugs, drug candidates, and their targets

A Bahuguna, DS Rawat - Medicinal research reviews, 2020 - Wiley Online Library
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers

RS Wallis, M Maeurer, P Mwaba, J Chakaya… - The Lancet infectious …, 2016 - thelancet.com
Tuberculosis is the leading infectious cause of death worldwide, with 9· 6 million cases and
1· 5 million deaths reported in 2014. WHO estimates 480 000 cases of these were multidrug …

[HTML][HTML] Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden …

A Wahid, A Ghafoor, AW Khan, YM Al-Worafi… - Frontiers in …, 2022 - frontiersin.org
Objective: To compare the effectiveness of second line injectables containing shorter
(duration 9–12 months) and longer treatment regimens (LTR, duration≥ 20 months) among …

[图书][B] WHO consolidated guidelines on drug-resistant tuberculosis treatment

World Health Organization - 2019 - apps.who.int
Executive summary Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult
to treat than drug-susceptible ones, and threaten global progress towards the targets set by …

A trial of a shorter regimen for rifampin-resistant tuberculosis

AJ Nunn, PPJ Phillips, SK Meredith… - … England Journal of …, 2019 - Mass Medical Soc
Abstract Background Cohort studies in Bangladesh showed promising cure rates among
patients with multidrug-resistant tuberculosis who received existing drugs in regimens …

World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update

D Falzon, HJ Schünemann, E Harausz… - European …, 2017 - Eur Respiratory Soc
Antimicrobial resistance is a major global concern. Tuberculosis (TB) strains resistant to
rifampicin and other TB medicines challenge patient survival and public health. The World …

[图书][B] Global tuberculosis report 2013

World Health Organization - 2013 - books.google.com
This is the eighteenth global report on tuberculosis (TB) published by WHO in a series that
started in 1997. It provides a comprehensive and up-to-date assessment of the TB epidemic …

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

C Lange, I Abubakar, JWC Alffenaar, G Bothamley… - 2014 - Eur Respiratory Soc
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)
tuberculosis (TB) substantially challenges TB control, especially in the European Region of …

Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis

EA Kendall, MO Fofana, DW Dowdy - The Lancet Respiratory …, 2015 - thelancet.com
Background Multidrug-resistant (MDR) tuberculosis can be acquired through de-novo
mutation during tuberculosis treatment or through transmission from other individuals with …

Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

A Zumla, J Chakaya, R Centis, L D'Ambrosio… - The Lancet …, 2015 - thelancet.com
WHO estimates that 9 million people developed active tuberculosis in 2013 and 1· 5 million
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …