Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

Molecular evolution of antifungal drug resistance

N Robbins, T Caplan, LE Cowen - Annual review of …, 2017 - annualreviews.org
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients

R Bellmann, P Smuszkiewicz - Infection, 2017 - Springer
Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

[HTML][HTML] Functionalized niosomes as a smart delivery device in cancer and fungal infection

P Aparajay, A Dev - European journal of pharmaceutical sciences, 2022 - Elsevier
Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Electrospun nanofibres in drug delivery: advances in controlled release strategies

MK Gaydhane, CS Sharma, S Majumdar - RSC advances, 2023 - pubs.rsc.org
Emerging drug-delivery systems demand a controlled or programmable or sustained
release of drug molecules to improve therapeutic efficacy and patient compliance. Such …

Alginate nanoparticles as non-toxic delivery system for miltefosine in the treatment of candidiasis and cryptococcosis

CC Spadari, FWMS de Bastiani, LB Lopes… - International journal of …, 2019 - Taylor & Francis
Introduction and objective Previous studies indicate that miltefosine (MFS) may be an
alternative as an antifungal agent; however, it presents several adverse effects. Thus, the …

Membrane-interacting antifungal peptides

C Struyfs, BPA Cammue, K Thevissen - Frontiers in cell and …, 2021 - frontiersin.org
The incidence of invasive fungal infections is increasing worldwide, resulting in more than
1.6 million deaths every year. Due to growing antifungal drug resistance and the limited …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

New facets of antifungal therapy

YL Chang, SJ Yu, J Heitman, M Wellington, YL Chen - Virulence, 2017 - Taylor & Francis
Invasive fungal infections remain a major cause of morbidity and mortality in
immunocompromised patients, and such infections are a substantial burden to healthcare …