Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

Background Testicular architecture and sperm production are supported by a complex
network of communication between various cell types. These signals ensure fertility by …

A growing body of evidence demonstrates that fetal-derived tissue-resident macrophages
have developmental functions. It has been proposed that macrophages promote testicular …

The escalating prevalence of male infertility and decreasing trend in sperm quality have
been correlated with rapid industrialisation and the associated discharge of an excess of …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Persistent research over the past few decades has clearly established that the insulin-like
family of growth factors, which is composed of insulin and insulin-like growth factors 1 (IGF1) …

STUDY QUESTION What are the consequences of ageing on human Leydig cell number
and hormonal function? SUMMARY ANSWER Leydig cell number significantly decreases in …

Lead (Pb) exists widely in soil and seriously threatens agricultural soil and food crops. Pb
can cause serious damage to organs. In this study, the animal model of Pb-induced rat …

Male infertility (MI) is a complex multifactorial disease, and idiopathic infertility accounts for
30% of cases of MI. At present, the evidence for the effectiveness of empirical drugs is …