Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility

A Gupta, A Vats, A Ghosal, K Mandal, R Sarkar… - Cellular and Molecular …, 2022 - Springer
Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and
attain functional maturation post-birth to significantly augment germ cell (Gc) division and …

Zingiber officinale ethanolic extract attenuates oxidative stress, steroidogenic gene expression alterations, and testicular histopathology induced by sodium arsenite …

M Seif, T Abd El-Aziz, M Sayed, Z Wang - Environmental Science and …, 2021 - Springer
Arsenic (As) indelibly exists in the environment and may reach to a food chain. Flavors and
herbs are recognized sources of natural antioxidants that play imperative against harmful …

Exogenous oestrogen impacts cell fate decision in the developing gonads: a potential cause of declining human reproductive health

MK Stewart, DM Mattiske, AJ Pask - International Journal of Molecular …, 2020 - mdpi.com
The increasing incidence of testicular dysgenesis syndrome-related conditions and overall
decline in human fertility has been linked to the prevalence of oestrogenic endocrine …

Animal models of male reproductive ageing to study testosterone production and spermatogenesis

DF Carrageta, B Guerra-Carvalho, MA Spadella… - Reviews in Endocrine …, 2022 - Springer
Ageing is the time-dependent gradual decline of the functional characteristics in an
organism. It has been shown that it results in the loss of reproductive health and fertility. The …

Single‐cell transcriptome analysis of the germ cells and somatic cells during mitotic quiescence stage in goats

M Chen, N Wang, H Yang, D Liu, Y Gao… - The FASEB …, 2023 - Wiley Online Library
The mitotic quiescence of prospermatogonia is the event known to occur during genesis of
the male germline and is tied to the development of the spermatogenic lineage. The …

circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway

Q Bian, B Chen, B Weng, D Chu, X Tang, S Yan… - International Journal of …, 2021 - mdpi.com
Sertoli cells are the crucial coordinators to guarantee normal spermatogenesis and male
fertility. Although circular RNAs (circRNAs) exhibit developmental-stage-specific expression …

Retinoblastoma-E2F transcription factor interplay is essential for testicular development and male fertility

JA Mäkelä, J Toppari - Frontiers in Endocrinology, 2022 - frontiersin.org
The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators
of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal …

Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells

L Zhang, T Ma, Q Tao, W Tan, H Chen… - Journal of Animal …, 2020 - academic.oup.com
Immature Sertoli cell (SC) proliferation determines the final number of mature SCs and
further regulates spermatogenesis. Accumulating evidence demonstrated that microRNAs …

Pendimethalin induces apoptosis in testicular cells via hampering ER-mitochondrial function and autophagy

J Ham, W Lim, G Song - Environmental Pollution, 2021 - Elsevier
Pendimethalin (PDM) is a dinitroaniline crop pesticide that is extensively utilized worldwide.
However, the reproductive toxicity and cellular mechanisms of PDM have not been …

Assessment of Zearalenone-Induced Cell Survival and of Global Gene Regulation in Mouse TM4 Sertoli Cells

C Savard, S Gawhary, A Boyer, Y Chorfi - Toxins, 2022 - mdpi.com
Zearalenone (ZEA) is a non-steroidal xenoestrogen mycotoxin produced by many Fusarium
fungal species, which are common contaminants of cereal crops destined for worldwide …