Organoids as tools to investigate the molecular mechanisms of male infertility and its treatments
Organoids are three-dimensional structures characterized by cellular spatial organizations
and functions close to the native tissue they mimic. Attempts to create organoids originating …
and functions close to the native tissue they mimic. Attempts to create organoids originating …
Bifenthrin impairs the functions of Leydig and Sertoli cells in mice via mitochondrion-endoplasmic reticulum dysregulation
Bifenthrin (BF) is a synthetic insecticide that is widely used in fields, resulting in an increase
in its exposure to animals. However, reports on the toxic effects of BF on mammalian species …
in its exposure to animals. However, reports on the toxic effects of BF on mammalian species …
[HTML][HTML] Application of rat cryptorchidism model for the evaluation of mesenchymal stromal cell secretome regenerative potential
GD Sagaradze, NA Basalova, VI Kirpatovsky… - Biomedicine & …, 2019 - Elsevier
Male infertility represents a severe social and medical challenge. In recent years the
progress in regenerative medicine promoted the development of novel options to overcome …
progress in regenerative medicine promoted the development of novel options to overcome …
Genetic resistance to DEHP-induced transgenerational endocrine disruption
Di (2-ethylhexyl) phthalate (DEHP) interferes with sex hormones signaling pathways (SHP).
C57BL/6J mice prenatally exposed to 300 mg/kg/day DEHP develop a testicular dysgenesis …
C57BL/6J mice prenatally exposed to 300 mg/kg/day DEHP develop a testicular dysgenesis …
An Integrated analysis of network pharmacology, molecular docking, and experiment validation to explore the new candidate active component and mechanism of …
X Bai, Y Tang, Q Li, D Liu, G Liu, X Fan… - Drug Design …, 2021 - Taylor & Francis
Purpose One of the most common types of male infertility is recognized as
oligoasthenozoospermia (OA), characterized by low sperm count and quality in males. As a …
oligoasthenozoospermia (OA), characterized by low sperm count and quality in males. As a …
The single-cell chromatin accessibility landscape in mouse perinatal testis development
HC Suen, S Rao, ACS Luk, R Zhang, L Yang, H Qi… - Elife, 2023 - elifesciences.org
Spermatogenesis depends on an orchestrated series of developing events in germ cells and
full maturation of the somatic microenvironment. To date, the majority of efforts to study …
full maturation of the somatic microenvironment. To date, the majority of efforts to study …
Development and function of smooth muscle cells is modulated by Hic1 in mouse testis
In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of
sperm and luminal fluid, while secreting growth factors and extracellular matrix proteins to …
sperm and luminal fluid, while secreting growth factors and extracellular matrix proteins to …
Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency
Y Li, G Schang, Y Wang, X Zhou, A Levasseur… - …, 2018 - academic.oup.com
The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle
development in females and spermatogenesis in males. FSH is a heterodimer of the …
development in females and spermatogenesis in males. FSH is a heterodimer of the …
Gold nanoparticle: An efficient carrier for MCP I of Carica papaya seeds extract as an innovative male contraceptive in albino rats
I Mohammad - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
In this study, gold nanoparticles (AuNP) based delivery system was developed for proven
MCP I fraction of Carica papaya seeds as a male contraceptive to enhance targeted efficacy …
MCP I fraction of Carica papaya seeds as a male contraceptive to enhance targeted efficacy …
The role of estrogen receptors in rat Sertoli cells at different stages of development
C Macheroni, TFG Lucas, CS Porto - Heliyon, 2020 - cell.com
The aim of the study was to investigate the effects of estrogen receptors (ESR1 and ESR2)
on the expression of the proteins involved with proliferation (CCND1) and differentiation …
on the expression of the proteins involved with proliferation (CCND1) and differentiation …