Organoids as tools to investigate the molecular mechanisms of male infertility and its treatments

M Kanbar, M Vermeulen, C Wyns - Reproduction, 2021 - rep.bioscientifica.com
Organoids are three-dimensional structures characterized by cellular spatial organizations
and functions close to the native tissue they mimic. Attempts to create organoids originating …

Bifenthrin impairs the functions of Leydig and Sertoli cells in mice via mitochondrion-endoplasmic reticulum dysregulation

J Ham, S You, W Lim, G Song - Environmental Pollution, 2020 - Elsevier
Bifenthrin (BF) is a synthetic insecticide that is widely used in fields, resulting in an increase
in its exposure to animals. However, reports on the toxic effects of BF on mammalian species …

[HTML][HTML] Application of rat cryptorchidism model for the evaluation of mesenchymal stromal cell secretome regenerative potential

GD Sagaradze, NA Basalova, VI Kirpatovsky… - Biomedicine & …, 2019 - Elsevier
Male infertility represents a severe social and medical challenge. In recent years the
progress in regenerative medicine promoted the development of novel options to overcome …

Genetic resistance to DEHP-induced transgenerational endocrine disruption

L Stenz, R Rahban, J Prados, S Nef… - PLoS …, 2019 - journals.plos.org
Di (2-ethylhexyl) phthalate (DEHP) interferes with sex hormones signaling pathways (SHP).
C57BL/6J mice prenatally exposed to 300 mg/kg/day DEHP develop a testicular dysgenesis …

An Integrated analysis of network pharmacology, molecular docking, and experiment validation to explore the new candidate active component and mechanism of …

X Bai, Y Tang, Q Li, D Liu, G Liu, X Fan… - Drug Design …, 2021 - Taylor & Francis
Purpose One of the most common types of male infertility is recognized as
oligoasthenozoospermia (OA), characterized by low sperm count and quality in males. As a …

The single-cell chromatin accessibility landscape in mouse perinatal testis development

HC Suen, S Rao, ACS Luk, R Zhang, L Yang, H Qi… - Elife, 2023 - elifesciences.org
Spermatogenesis depends on an orchestrated series of developing events in germ cells and
full maturation of the somatic microenvironment. To date, the majority of efforts to study …

Development and function of smooth muscle cells is modulated by Hic1 in mouse testis

A Uchida, S Sakib, E Labit, S Abbasi, RW Scott… - …, 2020 - journals.biologists.com
In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of
sperm and luminal fluid, while secreting growth factors and extracellular matrix proteins to …

Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency

Y Li, G Schang, Y Wang, X Zhou, A Levasseur… - …, 2018 - academic.oup.com
The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle
development in females and spermatogenesis in males. FSH is a heterodimer of the …

Gold nanoparticle: An efficient carrier for MCP I of Carica papaya seeds extract as an innovative male contraceptive in albino rats

I Mohammad - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
In this study, gold nanoparticles (AuNP) based delivery system was developed for proven
MCP I fraction of Carica papaya seeds as a male contraceptive to enhance targeted efficacy …

The role of estrogen receptors in rat Sertoli cells at different stages of development

C Macheroni, TFG Lucas, CS Porto - Heliyon, 2020 - cell.com
The aim of the study was to investigate the effects of estrogen receptors (ESR1 and ESR2)
on the expression of the proteins involved with proliferation (CCND1) and differentiation …