Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

The bacterial chromosome must be efficiently compacted to fit inside the small and crowded
cell while remaining accessible for the protein complexes involved in replication …

LysR-type transcriptional regulators (LTTRs) form one of the largest families of bacterial
regulators. They are widely distributed and contribute to all aspects of metabolism and …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Histones, ubiquitous in eukaryotes as DNA-packing proteins, find their evolutionary origins
in archaea. Unlike the characterized histone proteins of a number of methanogenic and …

Thermoacidophilic archaea belonging to the order Sulfolobales thrive in extreme biotopes,
such as sulfuric hot springs and ore deposits. These microorganisms have been model …

Foreign AT-rich genes drive bacterial adaptation to new niches while challenging the
existing regulation network. Here we report that MucR, a conserved regulator in α …

Cyclic AMP (cAMP) is a ubiquitous second messenger synthesized by most living
organisms. In bacteria, it plays highly diverse roles in metabolism, host colonization, motility …

Nucleoid-associated proteins (NAPs) are crucial in organizing prokaryotic DNA and
regulating genes. Vital to these activities are complex nucleoprotein structures, however …

C-di-GMP is a bacterial second messenger that regulates diverse processes in response to
environmental or cellular cues. The nucleoid-associated protein (NAP) CdbA in Myxococcus …