[HTML][HTML] Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer

YX Lim, ML Mierzwa, MA Sartor, NJ D'Silva - Oncogene, 2023 - nature.com
The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most …

[HTML][HTML] Circulating human papillomavirus DNA in head and neck squamous cell carcinoma: possible applications and future directions

D Adilbay, S Lele, J Pang, A Asarkar, J Calligas… - Cancers, 2022 - mdpi.com
Simple Summary Circulating human papillomavirus DNA is a promising tool in the
management of HPV-positive oropharyngeal cancer. The potential use of this tool will …

Performance of liquid biopsy for diagnosis and surveillance of human papillomavirus–associated oropharyngeal cancer

RM Ferrandino, S Chen, C Kappauf… - … –Head & Neck …, 2023 - jamanetwork.com
Importance There is growing interest in the use of circulating plasma tumor human
papillomavirus (HPV) DNA for diagnosis and surveillance of patients with HPV-associated …

[HTML][HTML] Analytical validation of NavDx, a cfDNA-based fragmentomic profiling assay for HPV-driven cancers

A Gunning, S Kumar, CK Williams, BM Berger… - Diagnostics, 2023 - mdpi.com
The NavDx® blood test analyzes tumor tissue modified viral (TTMV)-HPV DNA to provide a
reliable means of detecting and monitoring HPV-driven cancers. The test has been clinically …

[HTML][HTML] The Lack of Standardized Outcomes for Surgical Salvage of HPV-Positive Recurrent Oropharyngeal Squamous Cell Carcinoma: A Systematic Scoping …

AN Taniguchi, SR Sutton, SA Nguyen, AE Kejner… - Cancers, 2023 - mdpi.com
Simple Summary Despite salvage surgery being a key treatment option for recurrent
oropharyngeal squamous cell carcinoma, it is unclear how human papillomavirus (HPV) …

[HTML][HTML] Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment

C McInnis, S Bhatia, B Vijaykumar, Q Tian… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background High-risk human papillomavirus (HPV) is a primary cause of an increasing
number of oropharyngeal squamous cell carcinomas (OPSCCs). The viral etiology of these …

Lead Time to Recurrence After Posttreatment Plasma and Saliva HPV DNA Testing in Patients With Low-Risk HPV Oropharynx Cancer

J Califano, A Yousef, H Mostafa… - … –Head & Neck …, 2023 - jamanetwork.com
Importance Head and neck squamous cell carcinoma is a highly lethal cancer that is often
associated with human papillomavirus (HPV). Recent studies have shown promise in the …

SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy

I Lo Cigno, F Calati, C Girone, C Borgogna… - British Journal of …, 2023 - nature.com
Background Our aim was to evaluate the efficacy and anti-cancer action of a precision
medicine approach involving a novel SIRT1-dependent pathway that, when disrupted, leads …

Posttreatment Head and Neck Cancer Imaging: Anatomic Considerations Based on Cancer Subsites

T Hiyama, Y Miyasaka, H Kuno, K Sekiya… - …, 2024 - pubs.rsna.org
Posttreatment imaging surveillance of head and neck cancer is challenging owing to
complex anatomic subsites and diverse treatment modalities. Early detection of residual …

Preoperative Circulating Tumor HPV DNA and Oropharyngeal Squamous Cell Disease

D Lam, NR Sangal, A Aggarwal… - … –Head & Neck …, 2024 - jamanetwork.com
Importance The utility of preoperative circulating tumor tissue-modified viral human
papillomavirus DNA (TTMV-HPV DNA) levels in predicting human papillomavirus (HPV) …