The immunomodulatory and anti-inflammatory role of polyphenols

N Yahfoufi, N Alsadi, M Jambi, C Matar - Nutrients, 2018 - mdpi.com
This review offers a systematic understanding about how polyphenols target multiple
inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear …

[HTML][HTML] Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

T Behl, T Rana, GH Alotaibi, M Shamsuzzaman… - Biomedicine & …, 2022 - Elsevier
Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

Curcumin—from molecule to biological function

T Esatbeyoglu, P Huebbe, IMA Ernst… - Angewandte Chemie …, 2012 - Wiley Online Library
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in
curry and gives curry powder its characteristic yellow color. As a consequence of its intense …

Diet-derived antioxidants and their role in inflammation, obesity and gut microbiota modulation

A Deledda, G Annunziata, GC Tenore, V Palmas… - Antioxidants, 2021 - mdpi.com
It is generally accepted that gut microbiota, inflammation and obesity are linked to the
development of cardiovascular diseases and other chronic/non-communicable pathological …

[PDF][PDF] Polyphenols, intracellular signalling and inflammation

C Santangelo, R Vari, B Scazzocchio… - … -istituto superiore di …, 2007 - researchgate.net
excessive inflammation is considered as a critical factor in many human diseases, including
cancer, obesity, type II diabetes, cardiovascular diseases, neurodegenerative diseases and …

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

G Solinas, C Vilcu, JG Neels, GK Bandyopadhyay… - Cell metabolism, 2007 - cell.com
Obesity-induced insulin resistance is a major factor in the etiology of type 2 diabetes, and
Jun kinases (JNKs) are key negative regulators of insulin sensitivity in the obese state …

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease

R Zenz, R Eferl, C Scheinecker, K Redlich… - Arthritis research & …, 2008 - Springer
Abstract Activator protein 1 (AP-1)(Fos/Jun) is a transcriptional regulator composed of
members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were …

Inflammatory activation of microglia and astrocytes in manganese neurotoxicity

RB Tjalkens, KA Popichak, KA Kirkley - Neurotoxicity of Metals, 2017 - Springer
Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early
as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1: 41–42, 1837). Extensive research …

AP-1 expression and its clinical relevance in immune disorders and cancer

S Trop-Steinberg, Y Azar - The American journal of the medical sciences, 2017 - Elsevier
The inflammatory response is known to have a significant role in certain autoimmune
diseases and malignancies. We review current knowledge regarding the functions of …

Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials

A Moussaieff, R Mechoulam - Journal of Pharmacy and …, 2009 - academic.oup.com
Objectives Despite its historical-religious, cultural and medical importance, Boswellia has
not been thoroughly studied, and gaps still exist between our knowledge of the traditional …