Short-term DAPT and DAPT de-escalation strategies for patients with acute coronary syndromes: a systematic review and network meta-analysis

T Kuno, A Watanabe, S Shoji, T Fujisaki… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Short-term (≤ 6 months) dual antiplatelet therapy (DAPT) and DAPT de-
escalation become attractive for patients with acute coronary syndrome. METHODS: A …

Differential Impact of Clinical Factors for Predicting High Platelet Reactivity on Clinical Outcomes in Acute Myocardial Infarction Patients Treated With Clopidogrel and …

H Goto, Y Saito, T Matsumoto, T Sato… - … of Atherosclerosis and …, 2023 - jstage.jst.go.jp
Aims: Several scoring systems, including the ABCD-GENE and HHD-GENE scores
incorporating clinical and genetic factors, have been developed to identify patients likely to …

[HTML][HTML] Abatement of potent P2Y12 antagonist-based dual antiplatelet therapy after coronary intervention: a network meta-analysis of randomized controlled trials

O El Alaoui El Abdallaoui, D Tornyos… - Frontiers In …, 2023 - frontiersin.org
Introduction Dual antiplatelet therapy (DAPT) including prasugrel or ticagrelor is
recommended in patients with acute coronary syndromes (ACS) treated with coronary …

Clinical Impact of CYP2C19 Genotype on Clopidogrel-Based Antiplatelet Therapy After Percutaneous Coronary Intervention

SH Lee, YH Jeong, D Hong, KH Choi, JM Lee… - Cardiovascular …, 2023 - jacc.org
Background Although there is a growing body of evidence that CYP2C19 genotyping can be
beneficial when considering treatment with clopidogrel after percutaneous coronary …

De-escalation strategies in patients with acute coronary syndrome: a step towards precision medicine

F Gragnano, A Capolongo, F Terracciano… - Expert Review of …, 2023 - Taylor & Francis
Introduction Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is a
cornerstone in the treatment of patients with acute coronary syndrome (ACS) undergoing …

High Platelet Reactivity Combined with CYP2C19 Genotype in Predicting Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention

SE Kim, HS Jeon, TH Go, JH Lee… - Clinical …, 2023 - Wiley Online Library
Loss‐of‐function (LoF) alleles of cytochrome P450 2C19 (CYP2C19), which are prevalent in
East Asians, are linked to high platelet reactivity (HPR) phenotype and poor prognosis. We …

Net clinical benefit of clopidogrel versus ticagrelor in elderly patients carrying CYP2C19 loss-of-function variants with acute coronary syndrome after percutaneous …

D Zhang, P Li, M Qiu, Z Liang, J He, Y Li, Y Han - Atherosclerosis, 2024 - Elsevier
Background and aims Elderly patients with acute coronary syndrome (ACS) tend to choose
clopidogrel over potent P2Y12 receptor inhibitor such as ticagrelor after percutaneous …

Safety and efficacy of selective, clopidogrel-based strategies in acute coronary syndrome: a study-level meta-analysis

G Patti, L Grisafi, EG Spinoni… - Thrombosis and …, 2022 - thieme-connect.com
Objectives To investigate outcomes with selective, clopidogrel-based therapies versus
conventional treatment in patients undergoing percutaneous coronary intervention (PCI) …

[HTML][HTML] Escalation and de-escalation of antiplatelet therapy after acute coronary syndrome or PCI: available evidence and implications for practice

F Gragnano, A Capolongo, F Terracciano… - Journal of Clinical …, 2022 - mdpi.com
Dual antiplatelet therapy (DAPT) is the gold standard for the antithrombotic management of
patients with an acute coronary syndrome (ACS) or undergoing percutaneous coronary …

Effects of omega-3, omega-6, and total dietary polyunsaturated fatty acids supplementation in patients with atherosclerotic cardiovascular disease: a systematic review …

S Luo, H Hou, Y Wang, Y Li, L Zhang, H Zhang… - Food & Function, 2023 - pubs.rsc.org
Background: Uncertainty exists about the link between omega-3 fatty acid, omega-6 fatty
acid, and total polyunsaturated fatty acid (PUFA) intake and mortality in atherosclerotic …