Evaluation of Potential Racial Disparities in CYP2C19‐Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention

LH Cavallari, NA Limdi, AL Beitelshees… - Clinical …, 2023 - Wiley Online Library
Black patients suffer worse outcomes after percutaneous coronary intervention (PCI) than
White patients. Inequities in antiplatelet prescribing may contribute to this health disparity …

2023 ESC Guidelines on ACS: what is new in antithrombotic therapy?

M Galli, F Andreotti, P Sabouret, F Gragnano - 2023 - academic.oup.com
Beyond late-breaking clinical trials, the presentation of the European Society of Cardiology
(ESC) Guidelines has become a highly anticipated event at the annual ESC Congress. This …

Reduced mortality with antiplatelet therapy deescalation after percutaneous coronary intervention in acute coronary syndromes: a meta-analysis

T Palmerini, AG Bruno, M Gasparini… - Circulation …, 2022 - Am Heart Assoc
Background: Antiplatelet therapy deescalation has been suggested as an alternative to
standard treatment with potent dual antiplatelet therapy (DAPT) for 1 year in low bleeding …

Current Strategies to Guide the Antiplatelet Therapy in Acute Coronary Syndromes

I Russo, CG Brookles, C Barale, E Melchionda… - International Journal of …, 2024 - mdpi.com
The role of antiplatelet therapy in patients with acute coronary syndromes is a moving target
with considerable novelty in the last few years. The pathophysiological basis of the treatment …

Approaches to de-escalation of antiplatelet treatment in stabilized post-myocardial infarction patients with high ischemic risk

PM Mazzone, DJ Angiolillo… - Expert Review of …, 2022 - Taylor & Francis
Introduction In patients with acute coronary syndromes (ACS) undergoing percutaneous
coronary intervention (PCI), dual antiplatelet therapy (DAPT) with a potent P2Y12 inhibitor is …

[HTML][HTML] Investigation of smoking on the antiplatelet response to clopidogrel: Unravelling the Smoker's Paradox.

FA Plakogiannis, J Weidmann, B Fraser… - … -Research and Practice, 2024 - Elsevier
The intricate relationship between smoking and the effects of the antiplatelet drug
clopidogrel has been termed the “smoker's paradox”. This paradox details the enhanced …

Periprocedural antithrombotic strategies in acute coronary syndromes undergoing percutaneous coronary intervention: Have we discarded bivalirudin too soon?

S Benenati, GL De Maria, F Della Mora… - Cardiovascular …, 2023 - Elsevier
Background Publication of the BRIGHT-4 trial results has restimulated discussion about the
optimal periprocedural antithrombotic strategy for patients undergoing percutaneous …

Clinician Response to Pharmacogenetic Clinical Decision Support Alerts

LK Lemke, EJ Cicali, R Williams… - Clinical …, 2023 - Wiley Online Library
The objective of this study was to characterize clinician response following standardization
of pharmacogenetic (PGx) clinical decision support alerts at University of Florida (UF) …

Gender differences in efficacy and safety of antiplatelet strategies for acute coronary syndromes

G Occhipinti, A Greco, DJ Angiolillo… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Dual antiplatelet therapy (DAPT) represents the cornerstone of secondary
prevention in patients presenting with acute coronary syndrome (ACS) and undergoing …

Antiplatelet De-Escalation Strategies in Patients Undergoing Percutaneous Coronary Intervention

A Spirito, SL Krishnan, D Capodanno… - Circulation …, 2024 - Am Heart Assoc
Dual antiplatelet therapy—the combination of aspirin and a P2Y12 inhibitor—remains the
standard antiplatelet regimen recommended to prevent ischemic complications immediately …