Personalised antiplatelet therapies for coronary artery disease: what the future holds

D Capodanno, DJ Angiolillo - European Heart Journal, 2023 - academic.oup.com
Coronary artery disease (CAD) is one of the leading causes of death globally, and
antiplatelet therapy is crucial for both its prevention and treatment. Antiplatelet drugs such as …

Short-term DAPT and DAPT de-escalation strategies for patients with acute coronary syndromes: a systematic review and network meta-analysis

T Kuno, A Watanabe, S Shoji, T Fujisaki… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Short-term (≤ 6 months) dual antiplatelet therapy (DAPT) and DAPT de-
escalation become attractive for patients with acute coronary syndrome. METHODS: A …

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

R De Caterina, S Agewall, F Andreotti… - European Heart …, 2022 - academic.oup.com
1University of Pisa and University Cardiology Division, Pisa University Hospital, Pisa, Italy;
and 2Fondazione VillaSerena per la Ricerca, Città Sant'Angelo, Pescara, Italy How to best …

Attitudes about pharmacogenomic testing vary by healthcare specialty

CL Preys, CL Blout Zawatsky, A Massmann… - …, 2023 - Taylor & Francis
Aim: To understand how attitudes toward pharmacogenomic (PGx) testing among
healthcare providers varies by specialty. Methods: Providers reported comfort ordering PGx …

Evaluation of race and ethnicity disparities in outcome studies of CYP2C19 genotype-guided antiplatelet therapy

AB Nguyen, LH Cavallari, JS Rossi… - Frontiers in …, 2022 - frontiersin.org
Dual antiplatelet therapy with a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) and
aspirin remains the standard of care for all patients undergoing percutaneous coronary …

[HTML][HTML] De-escalation of antiplatelet therapy in patients with coronary artery disease: time to change our strategy?

P Sabouret, L Spadafora, D Fischman, W Ullah… - European Journal of …, 2023 - Elsevier
Dual antiplatelet therapy (DAPT) is the gold standard after acute coronary syndromes (ACS)
or chronic coronary syndromes (CCS) undergoing percutaneous coronary intervention …

[HTML][HTML] Stratified medicine for acute and chronic coronary syndromes: A patient-tailored approach

RA Montone, T Ford, M Galli, R Rinaldi, A Bland… - Progress in …, 2024 - Elsevier
The traditional approach to management of cardiovascular disease relies on grouping
clinical presentations with common signs and symptoms into pre-specified disease …

Clinical impact of preemptive pharmacogenomic testing on antiplatelet therapy in a real-world setting

A Massmann, KD Christensen… - European Journal of …, 2024 - nature.com
CYP2C19 genotyping to guide antiplatelet therapy after patients develop acute coronary
syndromes (ACS) or require percutaneous coronary interventions (PCIs) reduces the …

Platelet reactivity and clinical outcomes after drug-eluting stent implantation: results from the PTRG-DES consortium

SJ Lee, JJ Cha, YH Jeong, SJ Hong, CM Ahn… - Cardiovascular …, 2022 - jacc.org
Background The long-term prognostic implication of platelet reactivity after percutaneous
coronary intervention (PCI) is not clearly known. Objectives The impacts of platelet reactivity …

[HTML][HTML] Bleeding complications in patients undergoing percutaneous coronary intervention

M Galli, R Laborante, F Andreotti, R Vergallo… - Reviews in …, 2022 - imrpress.com
Percutaneous coronary intervention (PCI) is considered a relatively safe procedure
associated with low rates of complications, but is inevitably associated with short and mid-to …