[HTML][HTML] Molecular genetics of early-onset Alzheimer's disease revisited
R Cacace, K Sleegers, C Van Broeckhoven - Alzheimer's & dementia, 2016 - Elsevier
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”
J Hardy - The FEBS journal, 2017 - Wiley Online Library
The cloning of APP and genetic analysis of families with Alzheimer's disease were both
reported in 1987 and much present work on the disease is based upon the foundations laid …
reported in 1987 and much present work on the disease is based upon the foundations laid …
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
A Goate, MC Chartier-Harlin, M Mullan, J Brown… - Nature, 1991 - nature.com
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
Increased risk of type 2 diabetes in Alzheimer disease
J Janson, T Laedtke, JE Parisi, P O'Brien… - Diabetes, 2004 - Am Diabetes Assoc
Alzheimer disease and type 2 diabetes are characterized by increased prevalence with
aging, a genetic predisposition, and comparable pathological features in the islet and brain …
aging, a genetic predisposition, and comparable pathological features in the islet and brain …
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
E Levy, MD Carman, IJ Fernandez-Madrid, MD Power… - Science, 1990 - science.org
An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with
hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel …
hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel …
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
J Murrell, M Farlow, B Ghetti, MD Benson - Science, 1991 - science.org
Alzheimer's disease is a form of localized amyloidosis characterized by cerebral cortical
amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of …
amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of …
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
Linkage analysis was used to search the genome for chromosomal regions harboring
familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant …
familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant …
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's
disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a …
disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a …
Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)
C Van Broeckhoven, J Haan, E Bakker, JA Hardy… - Science, 1990 - science.org
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an
autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by …
autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by …