[HTML][HTML] The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
[HTML][HTML] A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
[HTML][HTML] Crosstalk between apoptosis, necrosis and autophagy
Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …
which have been extensively studied. Although initially thought to constitute mutually …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
abstract ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1
signaling to autophagy, regulates early stages of autophagosome formation in response to …
signaling to autophagy, regulates early stages of autophagosome formation in response to …
Regulation of tumor progression by programmed necrosis
SY Lee, MK Ju, HM Jeon, EK Jeong… - Oxidative medicine …, 2018 - Wiley Online Library
Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
[PDF][PDF] mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation
Summary mTORC1 plays a key role in autophagy as a negative regulator. The currently
known targets of mTORC1 in the autophagy pathway mainly function at early stages of …
known targets of mTORC1 in the autophagy pathway mainly function at early stages of …
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target …
R Bago, N Malik, MJ Munson, AR Prescott… - Biochemical …, 2014 - portlandpress.com
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase)
phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns …
phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns …
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
JM Backer - Biochemical Journal, 2016 - portlandpress.com
The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …
The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis
L Ou, S Lin, B Song, J Liu, R Lai… - International journal of …, 2017 - Taylor & Francis
Graphene-based materials (GBMs) are widely used in many fields, including biomedicine.
To date, much attention had been paid to the potential unexpected toxic effects of GBMs …
To date, much attention had been paid to the potential unexpected toxic effects of GBMs …