Brain metastases in oncogene-addicted non-small cell lung cancer patients: incidence and treatment

J Remon, B Besse - Frontiers in Oncology, 2018 - frontiersin.org
Brain metastases (BM) are common in non-small cell lung cancer patients including in
molecularly selected populations, such as EGFR-mutant and ALK-rearranged tumors. They …

Risk factors for brain metastases in patients with non–small‐cell lung cancer

N An, W Jing, H Wang, J Li, Y Liu, J Yu… - Cancer medicine, 2018 - Wiley Online Library
Brain metastases (BM) are severe incidents in patients with non–small‐cell lung cancer
(NSCLC). The controversial value of prophylactic cranial irradiation (PCI) in NSCLC in terms …

[HTML][HTML] Correlation between EGFR mutation status and the incidence of brain metastases in patients with non-small cell lung cancer

L Li, S Luo, H Lin, H Yang, H Chen, Z Liao… - Journal of thoracic …, 2017 - ncbi.nlm.nih.gov
Background Lung cancer is the leading cause of cancer-related death worldwide. Numerous
studies have been performed to investigate the correlation between epidermal growth factor …

Molecular profiles of brain metastases: a focus on heterogeneity

S Ali, Z Górska, R Duchnowska, J Jassem - Cancers, 2021 - mdpi.com
Simple Summary Precision cancer medicine depends on the characterization of tumor
samples, usually by a single-tumor biopsy, to administer an optimal therapeutic. However …

Pulsatile Erlotinib in EGFR-positive non–small-cell lung cancer patients with leptomeningeal and brain metastases: review of the literature

J How, J Mann, AN Laczniak, MQ Baggstrom - Clinical Lung Cancer, 2017 - Elsevier
Patients with epidermal growth factor receptor (EGFR)-positive (EGFR+) non–small-cell lung
cancer (NSCLC) show improved response rates when treated with tyrosine kinase inhibitors …

Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model

PC Hsu, B Tian, YL Yang, YC Wang… - Oncology …, 2019 - spandidos-publications.com
Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis
especially for the 40% of patients who develop brain metastasis, and few treatment …

Risk factors for brain metastases in patients with renal cell carcinoma

ZB Ke, SH Chen, YH Chen, YP Wu, F Lin… - BioMed Research …, 2020 - Wiley Online Library
Background. Patients with brain metastases (BM) from renal cell carcinoma (RCC) were
considered to experience a poor prognosis. However, there is little knowledge on the risk …

Leptomeningeal disease and the evolving role of molecular targeted therapy and immunotherapy

KH Thomas, RA Ramirez - Ochsner Journal, 2017 - ochsnerjournal.org
Background: Leptomeningeal disease (LMD) is a complication that results from solid tumor
metastasis. Prognosis is extremely poor. As therapeutic options for solid tumors improve, the …

Osimertinib early dose reduction as a risk to brain metastasis control in EGFR‐mutant non‐small cell lung cancer

T Tozuka, R Noro, A Miyanaga, S Nakamichi… - Cancer …, 2023 - Wiley Online Library
Background The epidermal growth factor receptor (EGFR) mutation is a risk factor
associated with brain metastases (BMs) in patients with non‐small cell lung cancer …

[HTML][HTML] The role of metabolic tumor volume (MTV) measured by [18F] FDG PET/CT in predicting EGFR gene mutation status in non-small cell lung cancer

A Liu, A Han, H Zhu, L Ma, Y Huang, M Li, F Jin… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Many noninvasive methods have been explored to determine the mutation status of the
epidermal growth factor receptor (EGFR) gene, which is important for individualized …