Proteomics of post-translational modifications in colorectal cancer: Discovery of new biomarkers

G Zhu, L Jin, W Sun, S Wang, N Liu - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

[HTML][HTML] MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications

LA Bravo-Vázquez, N Frías-Reid… - Translational …, 2023 - Elsevier
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-
coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through …

[HTML][HTML] Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model …

E Hong, W Barczak, S Park, JS Heo, A Ooshima… - Cell Death & …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal type of cancer and the third
leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in …

[HTML][HTML] Combined analytical approach empowers precise spectroscopic interpretation of subcellular components of pancreatic cancer cells

K Szymoński, K Skirlińska-Nosek, E Lipiec… - Analytical and …, 2023 - Springer
The lack of specific and sensitive early diagnostic options for pancreatic cancer (PC) results
in patients being largely diagnosed with late-stage disease, thus inoperable and burdened …

Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics

Y Wang, X Liu, L Gong, W Ding, W Hao… - British Journal of …, 2023 - Wiley Online Library
Sunitinib is the first‐line drug for renal cell carcinoma (RCC) treatment. However, patients
who received sunitinib treatment will ultimately develop drug resistance after 6–15 months …

[HTML][HTML] An overview of epigenetic methylation in pancreatic cancer progression

Y Zhao, M Yang, S Wang, SJ Abbas, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Over the past decades, the aberrant epigenetic modification, apart from genetic alteration,
has emerged as dispensable events mediating the transformation of pancreatic cancer (PC) …

Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer

KC LaRue-Nolan, GL Raja Arul, AN Sigafoos… - Biochemical …, 2024 - portlandpress.com
Pancreatic cancer is a malignancy arising from the endocrine or exocrine compartment of
this organ. Tumors from exocrine origin comprise over 90% of all pancreatic cancers …

[HTML][HTML] Unveiling the Molecular Landscape of Pancreatic Ductal Adenocarcinoma: Insights into the Role of the COMPASS-like Complex

M Jamali, E Barar, J Shi - International Journal of Molecular Sciences, 2024 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is poised to become the second leading cause
of cancer-related death by 2030, necessitating innovative therapeutic strategies. Genetic …

Epigenomic interplay in tumor heterogeneity: Potential of epidrugs as adjunct therapy

S Rath, D Chakraborty, J Pradhan, MI Khan… - Cytokine, 2022 - Elsevier
Abstract “Heterogeneity” in tumor mass has immense importance in cancer progression and
therapy. The impact of tumor heterogeneity is an emerging field and not yet fully explored …

KDM3A promotes oral squamous cell carcinoma cell proliferation and invasion via H3K9me2 demethylation-activated DCLK1

L Yang, Q Zhang, Q Yang - Genes & Genomics, 2022 - Springer
Background Oral squamous cell carcinoma (OSCC) is a frequently-diagnosed malignancy
with high potential for proliferation and invasion. Histone methylation is known as a crucial …