Diagnosis of chronic myeloid leukemia (CML) is based on the detection of BCR-ABL gene or
Philadelphia chromosome (Ph chromosome), and fusion proteins with different sizes are …

Rapid and accurate imaging of the BCR/ABL fusion gene isoforms (eg, e13a2, e14a2 and
co‐expression type) of chronic myeloid leukemia (CML) is of vital importance to first‐line …

CRISPR-Cas12a is able to precisely recognize double-stranded DNA (dsDNA) containing
PAM sequence under the guidance of CRISPR RNA (crRNA) and release indiscriminate …

Cancer is known to result from a combination of a small number of genetic defects. However,
the specific combinations of mutations responsible for the vast majority of cancers have not …

Background Chronic mye-logenous leukemia (CML) has long been recognized as an entity
responsive to immunotherapeutic interventions. Despite the success of the tyrosine kinase …

For immunotherapy of residual disease in patients with Philadelphia-positive leukemias, the
BCR-ABL fusion regions are attractive disease-specific T-cell targets. We analyzed these …

HLA Class II Allele and Haplotype Frequencies in Iranian Patients with Leukemia Page 1
Copyright© 2007, IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. All rights …

BCR/ABL p210 fusion gene, the characteristic biomarker of chronic myelogenous leukemia
(CML), contains two different transcription isoforms, e13a2 and e14a2, which lead to …

Chronic myelogenous leukemia (CML) is characterized by the presence of Philadelphia
chromosome resulting from bcr/abl translocation. To clarify the association between HLA …

OBJETIVOS: O objetivo deste estudo foi investigar a freqüência de antígenos HLA Classe I
e de alelos HLA Classe II em 164 pacientes com vários tipos de leucemias: 35 pacientes …