Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that
will drive biological discovery and transform the field of cell and gene therapy. Here, we …

Localized expression of immunomodulatory molecules can stimulate immune responses
against tumors in the tumor microenvironment while avoiding toxicities associated with …

The loss‐of‐function of the proprotein convertase subtilisin–kexin type 9 (Pcsk9) gene has
been associated with significant reductions in plasma serum low‐density lipoprotein …

Rare muscular disorders (RMDs) are disorders that affect a small percentage of the
population. The disorders which are attributed to genetic mutations often manifest in the form …

Delivery of CRISPR/Cas9 ribonucleoproteins (RNPs) offers a powerful tool for therapeutic
genome editing. However, precise manipulation of CRISPR/Cas9 RNPs to switch the …

Cancer vaccine is one of the immunotherapeutic strategies aiming to effectively deliver
cancer antigens to professional antigen-presenting cells such as dendritic cells (DCs) …

Key to the widespread and secure application of genome editing tools is the safe and
effective delivery of multiple components of ribonucleoproteins (RNPs) into single cells …

Evading recognition of immune cells is a well-known strategy of tumors used for their
survival. One of the immune evasion mechanisms is the synthesis of kynurenine (KYN), a …

Genome editing mediated by CRISPR/Cas9 is an attractive weapon for cancer therapy.
However, in vivo delivery of CRISPR/Cas9 components to achieve therapeutic efficiency is …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR
associated protein 9 (CRISPR/Cas9) systems initiate a revolution in genome editing, which …