Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

Pharmacotherapy is an effective treatment modality across psychiatric disorders.
Nevertheless, many patients discontinue their medication at some point. Evidence-based …

Background: In patients attempting to discontinue their antidepressant medication, there
have been no prospective studies on patterns of withdrawal as a function of the rate of …

Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

Background Public Health England recently called for the establishment of services to help
people to safely stop prescribed drugs associated with dependence and withdrawal …

Approximately half of the tens of millions of people currently taking antidepressants will
experience withdrawal symptoms when they try to reduce or come off them. Nearly half of …

Introduction: Benzodiazepine tapering and cessation has been associated with diverse
symptom constellations of varying duration. Although described in the literature decades …

Abstract Deaths of Despair (DoD), or mortality resulting from suicide, drug overdose, and
alcohol-related liver disease, have been rising steadily in the United States over the last …

Slower tapering of antipsychotics may provide time for adaptations made to the presence of
the medications to resolve, thus reducing the disruption to homeostatic equilibrium caused …

While effective ways to prevent withdrawal symptoms from psychiatric drugs remain unclear,
a highly accepted clinical approach for treatment discontinuation is to gradually reduce …