Dysregulated protease activity is often implicated in the initiation of inflammation and
immune cell recruitment in gastrointestinal inflammatory diseases. Using N …

Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are intestinal complications characterized by chronic inflammation, autophagy …

Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global
socioeconomic impact are increasing. While the role of host genetics and immunity is well …

Serine proteases have been long recognized to coordinate many physiological processes
and play key roles in regulating the inflammatory response. Accordingly, their dysregulation …

Simple Summary Chronic inflammatory enteropathies (CIEs) in dogs are currently classified
according to clinical response to sequential treatment trials. The resulting recognized …

Objective Multiple proteinases are present in the synovial fluid (SF) of an arthritic joint. We
aimed to identify inflammatory cell populations present in psoriatic arthritis (PsA) SF …

Dysregulation of the proteolytic balance is often associated with diseases. Serine proteases
and matrix metalloproteases are involved in a multitude of biological processes and notably …

The pathogenesis and course of inflammatory bowel diseases are related to both immune
system disorders and dysfunction of colon permeability. Moreover, co-existing diseases in …

About 70% of the drugs in use are derived from natural products, either used directly or in
chemically modified form. Among all possible small molecules (not greater than 5 kDa), only …

Background: Serine proteases are believed to play a key role in the origin of abdominal pain
in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post …