Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections

R Ramakrishnan, AK Singh, S Singh… - Journal of Biological …, 2022 - ASBMB
Drug resistance by pathogenic microbes has emerged as a matter of great concern to
mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms …

Small-molecule inhibition of bacterial biofilm

A Ghosh, N Jayaraman, D Chatterji - ACS omega, 2020 - ACS Publications
Antibiotic resistance is a massive and serious threat to human welfare and healthcare. Apart
from being genetically resistant to antibiotics, the other important mechanism by which …

Pseudomonas aeruginosa Biofilm Formation and Its Control

A Vetrivel, M Ramasamy, P Vetrivel, S Natchimuthu… - Biologics, 2021 - mdpi.com
Microbes are hardly seen as planktonic species and are most commonly found as biofilm
communities in cases of chronic infections. Biofilms are regarded as a biological condition …

Advanced strategies for combating bacterial biofilms

JY Sharahi, T Azimi, A Shariati, H Safari… - Journal of cellular …, 2019 - Wiley Online Library
Biofilms are communities of microorganisms that are formed on and attached to living or
nonliving surfaces and are surrounded by an extracellular polymeric material. Biofilm …

Biofilms: microbial shelters against antibiotics

S Hathroubi, MA Mekni, P Domenico… - Microbial Drug …, 2017 - liebertpub.com
Biofilms are communities of aggregated bacterial cells embedded in a self-produced
extracellular polymeric matrix. Biofilms are recalcitrant to antibiotic treatment and immune …

Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems

CR Thorn, PL Howell, DJ Wozniak, CA Prestidge… - Advanced Drug Delivery …, 2021 - Elsevier
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …

In diabetic foot infections antibiotics are to treat infection, not to heal wounds

M Abbas, I Uçkay, BA Lipsky - Expert opinion on pharmacotherapy, 2015 - Taylor & Francis
Introduction: Diabetic foot ulcers, especially when they become infected, are a leading
cause of morbidity and may lead to severe consequences, such as amputation. Optimal …

Approaches to targeting bacterial biofilms in cystic fibrosis airways

I Martin, V Waters, H Grasemann - International Journal of Molecular …, 2021 - mdpi.com
The treatment of lung infection in the context of cystic fibrosis (CF) is limited by a biofilm
mode of growth of pathogenic organisms. When compared to planktonically grown bacteria …

Novel formulations for antimicrobial peptides

AM Carmona-Ribeiro, LDM Carrasco - International journal of molecular …, 2014 - mdpi.com
Peptides in general hold much promise as a major ingredient in novel supramolecular
assemblies. They may become essential in vaccine design, antimicrobial chemotherapy …

[HTML][HTML] Bioactive antimicrobial peptides as therapeutic agents for infected diabetic foot ulcers

J Da Silva, EC Leal, E Carvalho - Biomolecules, 2021 - mdpi.com
Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic
patients and representing a leading cause of non-traumatic amputations. Notably, the risk of …