Advanced strategies for combating bacterial biofilms

JY Sharahi, T Azimi, A Shariati, H Safari… - Journal of cellular …, 2019 - Wiley Online Library
Biofilms are communities of microorganisms that are formed on and attached to living or
nonliving surfaces and are surrounded by an extracellular polymeric material. Biofilm …

Pseudomonas aeruginosa Biofilm Formation and Its Control

A Vetrivel, M Ramasamy, P Vetrivel, S Natchimuthu… - Biologics, 2021 - mdpi.com
Microbes are hardly seen as planktonic species and are most commonly found as biofilm
communities in cases of chronic infections. Biofilms are regarded as a biological condition …

Biofilms: microbial shelters against antibiotics

S Hathroubi, MA Mekni, P Domenico… - Microbial Drug …, 2017 - liebertpub.com
Biofilms are communities of aggregated bacterial cells embedded in a self-produced
extracellular polymeric matrix. Biofilms are recalcitrant to antibiotic treatment and immune …

Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems

CR Thorn, PL Howell, DJ Wozniak, CA Prestidge… - Advanced Drug Delivery …, 2021 - Elsevier
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …

In diabetic foot infections antibiotics are to treat infection, not to heal wounds

M Abbas, I Uçkay, BA Lipsky - Expert opinion on pharmacotherapy, 2015 - Taylor & Francis
Introduction: Diabetic foot ulcers, especially when they become infected, are a leading
cause of morbidity and may lead to severe consequences, such as amputation. Optimal …

Approaches to targeting bacterial biofilms in cystic fibrosis airways

I Martin, V Waters, H Grasemann - International Journal of Molecular …, 2021 - mdpi.com
The treatment of lung infection in the context of cystic fibrosis (CF) is limited by a biofilm
mode of growth of pathogenic organisms. When compared to planktonically grown bacteria …

Novel formulations for antimicrobial peptides

AM Carmona-Ribeiro, LDM Carrasco - International journal of molecular …, 2014 - mdpi.com
Peptides in general hold much promise as a major ingredient in novel supramolecular
assemblies. They may become essential in vaccine design, antimicrobial chemotherapy …

[HTML][HTML] Bioactive antimicrobial peptides as therapeutic agents for infected diabetic foot ulcers

J Da Silva, EC Leal, E Carvalho - Biomolecules, 2021 - mdpi.com
Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic
patients and representing a leading cause of non-traumatic amputations. Notably, the risk of …

Combinatorial effects of antibiotics and enzymes against dual-species Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the wound-like medium

R Fanaei Pirlar, M Emaneini, R Beigverdi, M Banar… - Plos one, 2020 - journals.plos.org
Bacterial biofilms are one of the major issues in the treatment of chronic infections such as
chronic wounds, where biofilms are typically polymicrobial. The synergy between species …

A review on biofilms and the currently available antibiofilm approaches: matrix-destabilizing hydrolases and anti-bacterial peptides as promising candidates for the …

M Akbarian, SH Chen, M Kianpour, F Farjadian… - International Journal of …, 2022 - Elsevier
Biofilms are communities of microorganisms that can be harmful and/or beneficial,
depending on location and cell content. Since in most cases (such as the formation of …