Combinatorial effects of antibiotics and enzymes against dual-species Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the wound-like medium

R Fanaei Pirlar, M Emaneini, R Beigverdi, M Banar… - Plos one, 2020 - journals.plos.org
Bacterial biofilms are one of the major issues in the treatment of chronic infections such as
chronic wounds, where biofilms are typically polymicrobial. The synergy between species …

A review on biofilms and the currently available antibiofilm approaches: matrix-destabilizing hydrolases and anti-bacterial peptides as promising candidates for the …

M Akbarian, SH Chen, M Kianpour, F Farjadian… - International Journal of …, 2022 - Elsevier
Biofilms are communities of microorganisms that can be harmful and/or beneficial,
depending on location and cell content. Since in most cases (such as the formation of …

Emerging contact-killing antibacterial strategies for developing anti-biofilm dental polymeric restorative materials

H Mitwalli, R Alsahafi, AA Balhaddad, MD Weir… - Bioengineering, 2020 - mdpi.com
Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored
fillings, sealing root canal systems, and many other dental restorative applications. However …

In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms

E Kamali, A Jamali, A Izanloo, A Ardebili - BMC microbiology, 2021 - Springer
Background Biofilms are a main pathogenicity feature of Pseudomonas aeruginosa and has
a significant role in antibiotic resistance and persistent infections in humans. We …

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections

JM Gilbertie, LV Schnabel, NJ Hickok, ME Jacob… - PloS one, 2019 - journals.plos.org
Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat
in both veterinary and human clinical practice. Biofilms, in the form of free-floating clumps or …

Role of the pre-neck appendage protein (Dpo7) from phage vB_SepiS-phiIPLA7 as an anti-biofilm agent in staphylococcal species

D Gutiérrez, Y Briers, L Rodríguez-Rubio… - Frontiers in …, 2015 - frontiersin.org
Staphylococcus epidermidis and Staphylococcus aureus are important causative agents of
hospital-acquired infections and bacteremia, likely due to their ability to form biofilms. The …

Novel treatment strategies for biofilm-based infections

C Vuotto, G Donelli - Drugs, 2019 - Springer
Biofilm-growing cells show an enhanced antimicrobial tolerance with respect to the same
cells growing in a free-floating way. This is due to physical or chemical diffusion barriers and …

Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Y Hu, X Zhang, S Deng, C Yue, X Jia… - Frontiers in Microbiology, 2023 - frontiersin.org
Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely
attached to the surface of medical instruments, making it one of the most common pathogens …

Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation

MJ Pestrak, TT Gupta, DH Dusane, DV Guzior… - PLoS …, 2020 - journals.plos.org
Periprosthetic joint infections (PJIs) are a devastating complication that occurs in 2% of
patients following joint replacement. These infections are costly and difficult to treat, often …

Nanofibers: an effective biomedical tool for burn management

S Sen, AP Kumbhar, JR Patil, OP Ranjan - Journal of Drug Delivery …, 2023 - Elsevier
Burn is considered as critical medical condition which need a continuous monitoring for
treatment. The therapeutic strategy is depended on the nature and depth of burn wound and …