Peptides as a strategy against biofilm-forming microorganisms: structure-activity relationship perspectives

RG Von Borowski, AJ Macedo, SCB Gnoatto - European Journal of …, 2018 - Elsevier
Biofilm forming microorganisms substantially enhance their virulence and drug resistance
causing and alternatives are need to combat this health problem. In this context, peptides …

[HTML][HTML] Improved wound closure rates and mechanical properties resembling native skin in murine diabetic wounds treated with a tropoelastin and collagen wound …

RS Kellar, RB Diller, AJ Tabor… - Journal of diabetes …, 2020 - ncbi.nlm.nih.gov
Chronic wounds in patients suffering from type II diabetes mellitus (DMII) where wounds
remain open with a complicated pathophysiology, healing, and recovery process is a public …

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

A Ahsan, N Thomas, TJ Barnes, S Subramaniam… - Pharmaceutics, 2024 - mdpi.com
The opportunistic bacteria growing in biofilms play a decisive role in the pathogenesis of
chronic infectious diseases. Biofilm-dwelling bacteria behave differently than planktonic …

Antiviral, Antimicrobial, and Antibiofilm Properties of Biosurfactants: Sustainable Use in Food and Pharmaceuticals

K Barrantes, JJ Araya, L Chacón… - Biosurfactants for a …, 2021 - Wiley Online Library
In an era of increasing drug resistance, the search for antimicrobial agents is crucial for the
development of a sustainable future. Biosurfactants are amphiphilic molecules with …

In vitro and in vivo evaluation of DNase I in reinstating antibiotic efficacy against Klebsiella pneumoniae biofilms

A Sharma, P Rishi, R Singh - Pathogens and Disease, 2023 - academic.oup.com
Klebsiella pneumoniae is an opportunistic pathogen associated with biofilm-based
infections, which are intrinsically antibiotic resistant. Extracellular DNA plays a crucial role in …

Molecular immunological mechanisms of impaired wound healing in diabetic foot ulcers (DFU), current therapeutic strategies and future directions

F Mohsin, S Javaid, M Tariq, M Mustafa - International …, 2024 - Elsevier
Diabetic foot ulcer (DFU) is a foremost cause of amputation in diabetic patients.
Consequences of DFU include infections, decline in limb function, hospitalization …

[HTML][HTML] Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme

JB Kaplan, SA Sukhishvili, M Sailer, K Kridin… - Pathogens, 2024 - mdpi.com
The extracellular matrix of most bacterial biofilms contains polysaccharides, proteins, and
nucleic acids. These biopolymers have been shown to mediate fundamental biofilm-related …

Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii

SL Rajangam, MK Narasimhan - Future Microbiology, 2024 - Taylor & Francis
A higher prevalence of Acinetobacter baumannii infections and mortality rate has been
reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of A …

[HTML][HTML] Dual functioned pegylated phospholipid micelles containing cationic antimicrobial decapeptide for treating sepsis

W Lee, EJ Park, G Min, J Choi, DH Na, JS Bae - Theranostics, 2017 - ncbi.nlm.nih.gov
Despite intensive investigation of molecular mechanisms underlying the pathogenesis of
sepsis, many aspects of sepsis remain unresolved; this hampers the development of …

An electrochemical strategy with molecular beacon and hemin/G-quadruplex for the detection of Clostridium perfringens DNA on screen-printed electrodes

D Jiang, F Liu, L Zhang, L Liu, C Liu, X Pu - RSC advances, 2014 - pubs.rsc.org
C. perfringens is a prevalent pathogen that causes infectious diseases. It becomes viable
easily but often cannot be cultured and thus escapes detection. Here, we describe an …