Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
H Hu, Y Cai, Y Shi, S Zhang, X Yu, T Ma, S Liao - Iscience, 2024 - cell.com
The NLRP3 inflammasome plays a pivotal role in various chronic inflammation-driven
human diseases. However, no drugs specifically targeting NLRP3 inflammasome have been …
human diseases. However, no drugs specifically targeting NLRP3 inflammasome have been …
[HTML][HTML] Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis
S Li, X Xue, H Zhang, L Jiang, Y Zhang, X Zhu… - Chemico-Biological …, 2024 - Elsevier
Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal
role. Analysis of Gene Expression Omnibus (GEO) mouse sepsis datasets revealed the …
role. Analysis of Gene Expression Omnibus (GEO) mouse sepsis datasets revealed the …
Extracellular histones promote TWIK2-dependent potassium efflux and associated NLRP3 activation in alveolar macrophages during sepsis-induced lung injury
J Yu, Y Fu, N Zhang, J Gao, Z Zhang, X Jiang… - Inflammation …, 2024 - Springer
Methods and results We conducted experiments using cecal ligation and puncture (CLP)
C57BL/6 mice and extracellular histone-stimulated LPS-primed MH-S cells. The results …
C57BL/6 mice and extracellular histone-stimulated LPS-primed MH-S cells. The results …
[HTML][HTML] KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye
K Liao, H Zeng, X Yang, D He… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: The purpose of this study was to elucidate the involvement of potassium two pore
domain channel subfamily K member 5 (KCNK5)-mediated potassium efflux in the …
domain channel subfamily K member 5 (KCNK5)-mediated potassium efflux in the …
Purinergic P2X Receptors as Therapeutic Targets
Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across
membranes. P2X receptors are assembled as trimers from three identical subunits …
membranes. P2X receptors are assembled as trimers from three identical subunits …
Immune Cell Ion Channels as Therapeutic Targets
A Selezneva, AJ Gibb, D Willis - Ion Channels as Targets in Drug …, 2024 - Springer
The immune system and its components represent the body's defensive apparatus against
microbes, toxins, trauma, and neoplasms. Consisting of a complex network of cellular and …
microbes, toxins, trauma, and neoplasms. Consisting of a complex network of cellular and …
[PDF][PDF] Die Rolle von Sphingosin-1-phosphat und Sphingosin-1-phosphat Rezeptor 3 bei der Restenose
M von Lucadou - 2023 - ediss.sub.uni-hamburg.de
Im zweiten Teil dieser Arbeit wurden in Blutproben von Patienten mit einer Stenose der A.
carotis oder einer pAVK die Konzentration von S1P und den Zytokinen (IL1B, IL10 und …
carotis oder einer pAVK die Konzentration von S1P und den Zytokinen (IL1B, IL10 und …