Abstract Cisplatin (cis-diammine-dichloro-platinum II) was initially discovered to prevent the
growth of Escherichia coli and was further recognized for its anti-neoplastic and cytotoxic …

Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

A fundamental question in cancer biology is whether cells with tumorigenic potential are
common or rare within human cancers. Studies on diverse cancers, including melanoma …

Background Incidence rates of testicular cancer (TC) have been increasing in many
countries since, at least, the mid-20th century without clear explanation. Examining the …

Cisplatin is a chemotherapeutic drug used for the treatment of a number of cancers. The
efficacy of cisplatin relies on its binding to DNA and the induction of cytotoxic DNA damage …

Anaplastic thyroid cancer (ATC) is a rare malignancy. While external beam radiation therapy
has improved locoregional control, the median survival of∼ 4 months has not changed in …

For over 30 years, sperm morphology assessment has been one of the most common tests
in evaluation of fertility. This review examines the clinical relevance of sperm morphology …

Background Testicular cancer is a rare tumor type accounting for 1% of malignancies in
men. It is, however, the most common cancer in young men in Western populations. The …

We conducted a genome-wide association study for testicular germ cell tumor, genotyping
298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating …

Simple Summary Cisplatin is successfully used for the treatment of various solid cancers.
Unfortunately, it shows no activity in colorectal cancer. The resistance phenotype of …