DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and
Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in …

Recent data on DNA sequencing of human tumours have established that cancer cells
contain thousands of mutations. These data support the concept that cancer cells express a …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic
factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

The American Association for Cancer Research has been the citadel for communicating
research on chemical carcinogens for over a century. It therefore seems appropriate that a …