Telomeres are terminal repetitive DNA sequences whose stability requires the coordinated
actions of telomere-binding proteins and the DNA replication and repair machinery …

Oxidative and alkylating DNA damage occurs under normal physiological conditions and
exogenous exposure to DNA damaging agents. To counteract DNA base damage, cells …

Human flap endonuclease 1 (FEN1) and related structure-specific 5'nucleases precisely
identify and incise aberrant DNA structures during replication, repair and recombination to …

Studies on cervical cancer are urgently required to improve clinical outcomes. As a major
anticancer drug for cervical cancer, paclitaxel has been used for many years in clinical …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

Viruses have been long known to perturb cell cycle regulators and key players of the DNA
damage response to benefit their life cycles. In the case of the human immunodeficiency …

The up-regulation of PRMT1 is critical to the cell growth and cancer progression of lung
cancer cells. In our research, we found that PRMT1 is important to the DNA repair ability and …

Flap endonuclease 1 (FEN1) and Dna2 endonuclease/helicase (Dna2) sequentially
coordinate their nuclease activities for efficient resolution of flap structures that are created …

Flap endonuclease 1 (FEN1) is an essential enzyme that removes RNA primers and base
lesions during DNA lagging strand maturation and long-patch base excision repair (BER). It …

Colorectal cancer (CRC) patients with APC mutations do not benefit from 5-FU therapy. It
was reported that APC physically interacts with POLβ and FEN1, thus blocking LP-BER via …