Simple Summary The liver is a multi-purpose organ, with involvement in bile secretion, and
lipid, carbohydrate and protein metabolism, as well as a number of other metabolic …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving
the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Liver metastases remain a major barrier to successful management of malignant disease,
particularly for cancers of the gastrointestinal tract but also for other malignancies, such as …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …