PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer
Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …
modulation of the activity of genes, impacting a variety of homeostatic processes involving …
Melatonin modulates tumor metabolism and mitigates metastasis
Introduction Melatonin, originally isolated from the mammalian pineal gland, was
subsequently identified in many animal cell types and in plants. While melatonin was …
subsequently identified in many animal cell types and in plants. While melatonin was …
lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
The role of ubiquitination and deubiquitination in PI3K/AKT/mTOR pathway: A potential target for cancer therapy
J Jin, J He, X Li, NI Xiaoqi, X Jin - Gene, 2023 - Elsevier
Abstract The PI3K/AKT/mTOR pathway controls key cellular processes, including
proliferation and tumor progression, and abnormally high activation of this pathway is a …
proliferation and tumor progression, and abnormally high activation of this pathway is a …
Beyond the genome: lncRNAs as regulators of the PI3K/AKT pathway in lung cancer
WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Lung cancer is a prevalent and devastating disease, representing a significant global health
burden. Despite advancements in therapeutic strategies, the molecular mechanisms …
burden. Despite advancements in therapeutic strategies, the molecular mechanisms …
The m6A methyltransferase METTL3 drives thyroid cancer progression and lymph node metastasis by targeting LINC00894
X Zhou, L Chang, Q Liang, R Zhao, Y Xiao, Z Xu… - Cancer Cell …, 2024 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) are significant contributors to
various human malignancies. The aberrant expression of lncRNA LINC00894 has been …
various human malignancies. The aberrant expression of lncRNA LINC00894 has been …
Integrated Omics Approach: Revealing the Mechanism of Auxenochlorella pyrenoidosa Protein Extract Replacing Fetal Bovine Serum for Fish Muscle Cell Culture
N Dong, B Jiang, Y Chang, Y Wang… - Journal of Agricultural …, 2024 - ACS Publications
The process of producing cell-cultured meat involves utilizing a significant amount of culture
medium, including fetal bovine serum (FBS), which represents a considerable portion of …
medium, including fetal bovine serum (FBS), which represents a considerable portion of …
A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
J Hu, J Liu, S Zhou, H Luo - Cancer Cell International, 2023 - Springer
Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human
chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic …
chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic …
The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5‐fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway
A Han, T Liu, P Du, M Wang, J Liu… - Molecular …, 2024 - Wiley Online Library
Gastric cancer (GC) is a prevalent malignancy of the digestive system. Distant metastasis
and chemotherapy resistance are the crucial obstacles to prognosis in GC. Recent research …
and chemotherapy resistance are the crucial obstacles to prognosis in GC. Recent research …