Exploring the impact of flavin homeostasis on cancer cell metabolism

A Nisco, M Tolomeo, M Scalise, K Zanier… - Biochimica et Biophysica …, 2024 - Elsevier
Flavins and their associated proteins have recently emerged as compelling players in the
landscape of cancer biology. Flavins, encompassing flavin mononucleotide (FMN) and flavin …

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

V Das, JH Miller, CG Alladi, N Annadurai… - Medicinal Research …, 2024 - Wiley Online Library
As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

[HTML][HTML] Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway

L Jiang, Z Zhang, Z Luo, L Li, S Yuan, M Cui… - Biomedicine & …, 2024 - Elsevier
Abstract Background Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …

[HTML][HTML] The combination therapy using tyrosine kinase receptors inhibitors and repurposed drugs to target patient-derived glioblastoma stem cells

M Kucinska, J Pospieszna, J Tang, N Lisiak… - Biomedicine & …, 2024 - Elsevier
The lesson from many studies investigating the efficacy of targeted therapy in glioblastoma
(GBM) showed that a future perspective should be focused on combining multiple target …

Developing theragnostics for Alzheimer's disease: Insights from cancer treatment

H Lee, HJ Choi, YJ Jeong, YH Na, JT Hong… - International Journal of …, 2024 - Elsevier
The prevalence of Alzheimer's disease (AD) and its associated economic and societal
burdens are on the rise, but there are no curative treatments for AD. Interestingly, this …

Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing

RR Malla, S Viswanathan, S Makena, S Kapoor… - Cancers, 2024 - mdpi.com
Simple Summary Drug repurposing is emerging as a promising avenue for addressing
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …

Geriatric Drug Delivery―Barriers, Current Technologies and the Road Ahead

EA Kean, OA Adeleke - Journal of Drug Targeting, 2024 - Taylor & Francis
The geriatric population encompasses the largest part of the health care system worldwide.
Chronic medical conditions are highly prevalent in the elderly, consequently, due to their …

Deciphering Immunodiffusion: In Silico Optimization for Faster Protein Diagnostics

C Liu, S Corrie, K Regenauer-Lieb, M Hu - Talanta, 2024 - Elsevier
Immunodiffusion tests offer a simple yet powerful method for detecting protein antigens, but
their long assay times hinder clinical utility. We unveil the complex interplay of parameters …

Impact of V9302, a Competitive Antagonist of Transmembrane Glutamine Flux on Reversal of Resistance in Breast Cancer Cell Lines

N Szemerédi, Z Schelz, DA Horvath, B Rácz… - Pharmaceutics, 2024 - mdpi.com
Chemotherapy is a known treatment modality that improves the long-term survival of breast
cancer patients. However, due to the resistance to numerous anticancer drugs, alternative …

Enhancing oncogenic signaling to kill cancer cells

M Noeparast, O Timofeev, M Pichler - Trends in Pharmacological Sciences, 2024 - cell.com
Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and
recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and …