Exploring the impact of flavin homeostasis on cancer cell metabolism
Flavins and their associated proteins have recently emerged as compelling players in the
landscape of cancer biology. Flavins, encompassing flavin mononucleotide (FMN) and flavin …
landscape of cancer biology. Flavins, encompassing flavin mononucleotide (FMN) and flavin …
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies
As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …
[HTML][HTML] Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway
L Jiang, Z Zhang, Z Luo, L Li, S Yuan, M Cui… - Biomedicine & …, 2024 - Elsevier
Abstract Background Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …
acts upstream of the Akt regulatory pathway and is abnormally expressed in many types of …
[HTML][HTML] The combination therapy using tyrosine kinase receptors inhibitors and repurposed drugs to target patient-derived glioblastoma stem cells
M Kucinska, J Pospieszna, J Tang, N Lisiak… - Biomedicine & …, 2024 - Elsevier
The lesson from many studies investigating the efficacy of targeted therapy in glioblastoma
(GBM) showed that a future perspective should be focused on combining multiple target …
(GBM) showed that a future perspective should be focused on combining multiple target …
Developing theragnostics for Alzheimer's disease: Insights from cancer treatment
H Lee, HJ Choi, YJ Jeong, YH Na, JT Hong… - International Journal of …, 2024 - Elsevier
The prevalence of Alzheimer's disease (AD) and its associated economic and societal
burdens are on the rise, but there are no curative treatments for AD. Interestingly, this …
burdens are on the rise, but there are no curative treatments for AD. Interestingly, this …
Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing
RR Malla, S Viswanathan, S Makena, S Kapoor… - Cancers, 2024 - mdpi.com
Simple Summary Drug repurposing is emerging as a promising avenue for addressing
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …
Geriatric Drug Delivery―Barriers, Current Technologies and the Road Ahead
EA Kean, OA Adeleke - Journal of Drug Targeting, 2024 - Taylor & Francis
The geriatric population encompasses the largest part of the health care system worldwide.
Chronic medical conditions are highly prevalent in the elderly, consequently, due to their …
Chronic medical conditions are highly prevalent in the elderly, consequently, due to their …
Deciphering Immunodiffusion: In Silico Optimization for Faster Protein Diagnostics
Immunodiffusion tests offer a simple yet powerful method for detecting protein antigens, but
their long assay times hinder clinical utility. We unveil the complex interplay of parameters …
their long assay times hinder clinical utility. We unveil the complex interplay of parameters …
Impact of V9302, a Competitive Antagonist of Transmembrane Glutamine Flux on Reversal of Resistance in Breast Cancer Cell Lines
N Szemerédi, Z Schelz, DA Horvath, B Rácz… - Pharmaceutics, 2024 - mdpi.com
Chemotherapy is a known treatment modality that improves the long-term survival of breast
cancer patients. However, due to the resistance to numerous anticancer drugs, alternative …
cancer patients. However, due to the resistance to numerous anticancer drugs, alternative …
Enhancing oncogenic signaling to kill cancer cells
M Noeparast, O Timofeev, M Pichler - Trends in Pharmacological Sciences, 2024 - cell.com
Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and
recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and …
recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and …