Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …

Introduction: The concept of allostatic load encompasses the cumulative effects of both
ordinary daily life events as well as major challenges, and also includes related health …

Social nonhuman animals are powerful models for studying underlying factors related to
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …

In numerous brain structures, insulin signaling modulates the homeostatic processes,
sensitivity to reward pathways, executive function, memory, and cognition. Through human …

Background: Neighborhoods are critical to understanding how environments influence
health outcomes. Prolonged environmental stressors, such as a lack of green spaces and …

The lifespan is influenced by adverse childhood experiences that create predispositions to
poor health outcomes. Here we propose an allostatic framework of childhood experiences …

Background While adverse childhood experiences (ACEs) predict poorer mental health
across the life course, positive childhood experiences (PCEs) predict better mental health. It …

Background Allostatic load (AL) indicates the cumulative impact of stress on homeostatic
mechanisms. Depression and AL have been associated with cognitive deficits, but it is …

Background Childhood maltreatment (CM) has been linked to higher levels of allostatic load
(AL) and educational achievement is a possible pathway and may differ across gender. It is …

Background Childhood maltreatment is linked with health problems in adulthood.
Theoretical models suggest that maltreatment leads to dysregulation in several bodily …