Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Joint analysis of single-cell genomics data from diseased tissues and a healthy reference
can reveal altered cell states. We investigate whether integrated collections of data from …

Wnt signaling pathways are tightly controlled under a physiological condition, under which
they play key roles in many biological functions, including cell fate specification and tissue …

Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the
gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can …

Idiopathic pulmonary fibrosis (IPF) is a progressive clinical syndrome of fatal outcome. The
lack of information about the signaling pathways that sustain fibrosis and the myofibroblast …

Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of
mortality. The potential factors causing PF include viral infections, radiation exposure, and …

Oxidative stress has been associated with a number of human fibrotic diseases, including
idiopathic pulmonary fibrosis (IPF). Although oxidative stress is associated with both fibrosis …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease with no cure. Although
IPF is widely regarded as a disease of aging, the cellular mechanisms that contribute to this …

Abstract Sphingosine-1-phosphate (S1P), a simple, bioactive sphingolipid metabolite, plays
a key role, both intracellularly and extracellularly, in various cellular processes such as …