Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
SS Cao, RJ Kaufman - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …
Obesity induces ovarian inflammation and reduces oocyte quality
In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …
Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation
Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …
Lipid metabolism and endometrial receptivity
T Yang, J Zhao, F Liu, Y Li - Human Reproduction Update, 2022 - academic.oup.com
BACKGROUND Obesity has now been recognized as a high-risk factor for reproductive
health. Although remarkable advancements have been made in ART, a considerable …
health. Although remarkable advancements have been made in ART, a considerable …
Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging
A Capalbo, ER Hoffmann, D Cimadomo… - Human reproduction …, 2017 - academic.oup.com
ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors
Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …
programs the metabolism of offspring; however, the temporal and mechanistic origins of …
[PDF][PDF] Mitochondria and lipid metabolism in mammalian oocytes and early embryos
J Bradley, K Swann - International Journal of Developmental Biology, 2019 - core.ac.uk
Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …
Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development
L Zhang, J Zhao, SM Lam, L Chen, Y Gao, W Wang… - Nature Cell …, 2024 - nature.com
Lipids are indispensable for energy storage, membrane structure and cell signalling.
However, dynamic changes in various categories of endogenous lipids in mammalian early …
However, dynamic changes in various categories of endogenous lipids in mammalian early …
Improvement effect of metformin on female and male reproduction in endocrine pathologies and its mechanisms
AO Shpakov - Pharmaceuticals, 2021 - mdpi.com
Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …
combination with other drugs, restores the ovarian function in women with polycystic ovary …